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Purpose: In this study, we applied platelet rich fibrin (PRF) and pure olive oil on the incision surfaces of rats. We aimed to examine whether PRF may be used safely to prevent peritoneal adhesions. Materials and Methods: Fourty rats were divided into 4 groups (n=8). Eight rats, not included in the study groups, were used to obtain PRF material. Group 1 had no surgical procedure, Group 2 was operated without medication, Group 3 was operated and received 1cc olive oil, Group 4 was operated and received 1 cc PRF. After 21 days, cecum areas were examined histopathologically. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and platelet-derived growth factor (PDGF) levels were measured in serum by ELISA. Results: The adhesion scores and severity of fibrosis in Group 3 and 4 were significantly lower than Group 2. Plasma TNF-α value was significantly higher in Group 2 than Group 4. Plasma PDGF value was significantly higher in Group 2 than Group 3 and 4. Discussion: PRF reduced intestinal adhesion by inhibiting the proliferation of fibroblasts and inflammatory cells, and promoting the proliferation of mesothelial cells. PRF has anti-inflammatory effect and prevented postop adhesions, based mainly on growth factors and cytokines in its content.

Purpose: The primary aim of thşis study was to evaluate difference in the number of patients with tru-cut biopsies to diagnose breast lesions between non-pandemic and pandemic periods. Materials and Methods: In this study, the nonpandemic period and the pandemic period were compared, the periods for the pandemic times, between March 1, 2018, and 29 February 2020, and for the nonpandemic period, 1 March 2020 to 12 March 2022 to 12 March 2022. In each period, we have included all the tru-cut biopsies for suspected breast cancer. During the pandemic and non-pandemic period, the number of tru-cut biopsies BI-RADS and histopathological findings of the patients who experienced tru-cut biopsies were compared. Results: The number of tru-cut biopsies performed during the nonpandemic and pandemic period was similar (1596, 1599). In the pandemic period, tru-cut biopsy histopathologic reports revealed that benign and high-risk cases decreased statistically, while invasive carcinoma cases increased by 1.9 (95% CI 1.6-2.2) times. During the pandemic period, US-guided BI-RADS 3 and BI-RADS 4a cases decreased statistically significantly, BBI-RADS 4b cases increased 1.4 (95% CI 1.1-2.2) times, BI-RADS 4c cases 1.7 (95% CI 1.2-2.2), BI-RADS 5 cases increased 2.1 (95% CI 1.4-3.1) times Conclusion: There was no significant change in tru-cut biopsy numbers compared to the period of the pandemic and the non-pandemic period. However, the stage of the cancers captured during the period of the pandemic was higher.

Purpose: Ovarian ischemia, which is known as one of the most common gynecologic surgery emergencies in women of all ages, is the distruption of the ovarian perfusion. Herein, we aimed to investigate the effect of tadalafil, a phosphodiesterase-5 inhibitor, at different doses and durations in the management of ovarian survival in ischemia-reperfusion injury model in rats. Materials and Materials and Methods: Thirty female Wistar albino rats were divided into five groups. Ovarian ischemia was induced by clamping the adnex of uterine tuba for three hours and reperfused for one hour. Drug treatments were given as follows: Group 1: saline (ischemic control), Group 2: tadalafil 1 mg/kg, Group 3: tadalafil 10 mg/kg, Group 4: tadalafil 1 mg/kg for 7 days, Group 5: tadalafil 10 mg/kg for 7 days. At the end of the treatments, ovaries were removed and evaluated for histopathological analysis. Results: Group 4 and Group 5 showed significant decrease in vascular congesion, hemorrhage, edema, neutrophilic infiltration compared to Group 1. All groups showed significant decrease in neutrophilic infiltration compared to Group 1. We found that treatment with tadalafil for 7 days significantly decreased the ovarian tissue damage scores in rats compared to the ischemic control. Conclusion: Our results showed that tadalafil treatment in ischemic ovarian injury is effective in limiting ovarian damage. The reduction in the tissue damage scores suggested that treatment with PDE5 inhibitors, such as tadalafil, may contribute to the healing of conservatively treated ovaries and may play a role in the treatment of adnexal torsion.

Amaç: Bu çalışma, bağırsak tıkanıklıklarının nadir nedenlerini ortaya koymayı ve kontrastlı veya kontrastsız bilgisayarlı tomografinin tanısal doğruluğunu karşılaştırmayı amaçlamaktadır.Gereç ve Yöntem: 15 Ocak 2009 ve 15 Haziran 2018 tarihleri arasında, acil serviste veya hastanede akut mekanik bağırsak tıkanıklığı tanısı alan hastalar retrospektif olarak değerlendirildi. Veriler hasta dosyalarından ve görüntüleme sisteminden elde edildi. Mekanik bağırsak tıkanıklığı tanısı; muayene, klinik bulgular ve bilgisayarlı tomografi tetkikine dayanarak koyuldu. Bulgular: Hastaların 46'sı kadın ve 41'i erkek ve yaş aralığı 20 ila 81 arasında idi. Mekanik tıkanıklığı olan hastalarda 58 (% 66.7) ince bağırsaktan ve 29 (% 33.3) kalın bağırsaktan kaynaklanmakta idi. Yaş, beden kitle indeksi ve kontrast kullanımı ile nadir görülen ince ve kalın barsak nedenleri karşılaştırıldığında, aralarında anlamlı bir fark saptanmadı. Altın standart cerrahi ile karşılaştırıldığında, kontrastlı veya kontrastsız bilgisayarlı tomografi bulgularının duyarlılık, özgüllük, pozitif prediktif değer, negatif prediktif değer ve tanısal doğruluğu sırası ile % 93,9, % 93.3, % 96.9, % 87.5, % 94 ve % 96.0, % 85.7, % 92.3, % 92.3, % 92.3 idi.Sonuç: Kontrastsız bilgisayarlı tomografi, bağırsak tıkanıklığının yerini, şiddetini ve etiyolojisini tanımlamak için kontrastlı bilgisayarlı tomografi ile karşılaştırıldığında benzer bir tanısal doğruluk, duyarlılık ve özgüllüğe sahip olduğu saptanmıştır.

Juvenile dermatomyositis is a multisystemic autoimmune disease with uncertain etiology. Both innate immunity and adaptive immunity play a role on the pathogenesis of the disease. Selective immunoglobulin A deficiency is the most common primary immunodeficiency. Association between immunoglobulin A deficiency and autoimmune diseases including few juvenile dermatomyositis patients have been reported. A previously healthy 15-year old girl was diagnosed with juvenile dermatomyositis according to Bohan and Peter criteria and selective immunoglobulin A deficiency due to the low level of immunoglobulin A (

Mikst konnektif doku hastalığı birden fazla bağ doku hastalığına ait bulgular ile karakterize otoimmün bir hastalıktır. U1 RNP’ye karşı yüksek titre otoantikorlar ile karakterizedir. Hastaların %23’ünün çocukluk çağında bulgu verdiği bildirilmiştir. Bu çalışmada, mikst konnektif doku hastalığı tanısı almış ve en az 2 yıl takip edilmiş olan 5 çocuk hastanın demografik ve klinik bulgularının, hastalık sonuçlarının geriye dönük incelenmesi hedeflenmiştir.

Amaç: Çalışmamızın amacı astımlı çocuklarda, düzenli egzersizin astım semptomları, astım tedavi ihtiyacı skoru, yaşam kalitesi ve solunum fonksiyonları üzerindeki etkilerini araştırmaktır.Gereç ve Yöntem: Bu çalışmaya 17 farklı okuldan 73 (32 erkek, 41 kız) astımlı öğrenci seçildi. İki yüz otuz iki öğrenciye çalışmanın başlangıcında solunum fonksiyon testi yapılıp, yaşam kalite skoru, astım tedavi ihtiyacı ve semptom skoru tespit edildi. Ortalama yaş 12±2,3 (7-16 yaş) idi. Yetmiş üç öğrencinin 27’si yüzme, 26’sı sokak basketbolu,11’i atletizm, 9’u ise badminton grubunda çalışmışlardı. Bağımsız değişkenlerin karşılaştırılmasında Student’s t–test kullanıldı.Bulgular: Sokak basketbolu ve badminton grubundaki hastaların semptom skorunda anlamlı azalma saptandı. Yüzme ve atletizm grubunda olan hastaların yaşam kalite skorlarında artış belirlendi. Yüzme, sokak basketbolu ve badminton grubundaki hastaların birinci saniye zorlu ekspirasyon volümü değerlerinde istatistiksel olarak anlamlı yükselme saptandı. Sonuç: Solunum fonksiyonları ve yaşam kalitesi üzerindeki etkileri nedeni ile düzenli egzersiz, çocukluk çağı astım tedavisinin bir parçası olmalıdır.

Purpose: This psychiatric and cardiological study aim to compared patients with normal coronary angiography and coronary hearth disease patients with respect to sociodemografic features, psychiatric comorbidities, anxiety and depression level, mental and physical quality of life. We also determined associated factors with normal coronary patients. Material and Methods: Eighty-seven patients with normal coronary angiography (NCA) and thirty-one coronary artery disease (CAD) patients were included the study after coronary angiography. Groups were compared with regard to sociodemographic characteristics, comorbid psychiatric disorders and Beck Anxiety (BAI) and Beck Depression (BDI) Inventories and Health Related Quality of Life (SF-36) scale scores. Results: There was statistically significant difference between the groups in terms of age, gender, marital status, occupation, family history for psychiatric disorders. Mental disorders were found in 82.8% of the patients with NCA and in 48.1% of the patients with angiographic coronary disease. The patients with NCA have a higher prevalence of psychiatric comorbidity, family history of psychiatric disorder, are relatively young, female and unmarried. There was significant difference in pain, general health and social function subgroups of quality of life scale between groups. The impact of mental and physical quality of life with NCA patients were as significant as those with CAD.Conclusion: The present study revealed that prevalence of psychiatric co morbidities is high and impairment in quality of life is notable in the patients with NCA patients