1. Neurological Disorders Associated with Glutamic Acid Decarboxylase Antibodies
- Author
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Kettia Alusma-Hibbert, Javed L Khanni, Kimberly Herard, Courtland R Samuels, and Patricio S Espinosa
- Subjects
Glutamate decarboxylase ,neurological symptoms ,Status epilepticus ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,medicine ,anti gad antibodies ,myasthenia gravis ,Palatal myoclonus ,Cerebellar ataxia ,biology ,business.industry ,Limbic encephalitis ,General Engineering ,medicine.disease ,Myasthenia gravis ,nervous system diseases ,guillan barre syndrome ,Neurology ,Immunology ,paraneoplastic ,biology.protein ,Other ,medicine.symptom ,Antibody ,business ,030217 neurology & neurosurgery ,Stiff person syndrome - Abstract
Anti-glutamic acid decarboxylase (GAD) antibodies have been discovered in a variety of neurological syndromes with unique presentations. These syndromes include limbic encephalitis (LE), stiff person syndrome (SPS), opsoclonus-myoclonus-ataxia syndrome, cerebellar ataxia, status epilepticus, and palatal myoclonus among others. We present two patients who presented with Guillain-Barré (GBS) and myasthenia gravis (MG) like syndromes, who were found to have anti-GAD antibodies. These case reports highlight the complex presentation of patients with neurological disorders associated with anti-GAD antibodies. The proper identification of anti-GAD antibody’s presence has proven to be beneficial in treatment and provide enhanced quality of life.
- Published
- 2019
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