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Start Over Descriptor "IGE" Journal current allergy and asthma reports
71 results on '"IGE"'

17. Basophil Activation Test: Old and New Applications in Allergy

Author

Alexandra F. Santos, Oliver Hemmings, Richard T McKendry, and Matthew Kwok

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Allergy, IgG, medicine.medical_treatment, Immunology, Basophil activation test, Basophil, Basophil degranulation, medicine.disease_cause, Immunoglobulin E, 03 medical and health sciences, 0302 clinical medicine, Immune system, Allergen, Diagnosis, medicine, Immunology and Allergy, biology, business.industry, Immunologic/Diagnostic Tests in Allergy (P Matricardi, Section Editor), Immunotherapy, medicine.disease, Basophil activation, 030104 developmental biology, medicine.anatomical_structure, 030228 respiratory system, biology.protein, IgE, business
Abstract

Purpose of Review The basophil activation test (BAT) using flow cytometry has supplanted traditional methods of measuring basophil degranulation using histamine and other mediator release, and can be used for clinical applications as well as to explore the immune mechanisms of effector cell response to allergen. This review discusses the advancements made in clinical, diagnostic and laboratory research of allergy utilizing an ever-evolving BAT. Recent Findings Being an in vitro surrogate of the allergic reaction that happens in vivo in the sick patient, the BAT can be used to support the diagnosis of various allergic conditions, such as food, drug, respiratory and insect venom allergies, and the assessment of clinical response to allergen-specific immunotherapy and other immunomodulatory treatments. The BAT can also be used for research purposes to explore the mechanisms of allergy and tolerance at the level of the basophil, for instance by manipulating IgE and IgG and their receptors and by studying intracellular signalling cascade in response to allergen. Summary This review covers the applications of the BAT to the clinical management of allergic patients and the increased understanding of the mechanisms of immune response to allergens as well as technological advancements made in recent years.

Published
2018

29. Suggested Improvements for the Allergenicity Assessment of Genetically Modified Plants Used in Foods

Author

Afua O. Tetteh and Richard E. Goodman

Subjects
Pulmonary and Respiratory Medicine, Food Safety, Food, Genetically Modified, Immunology, Genetically modified crops, Biology, Genetically modified, Article, Improvement, Per capita, Humans, Immunology and Allergy, Risk assessment, business.industry, Plants, Plants, Genetically Modified, Food safety, Genetically modified organism, Biotechnology, Allergenicity, Agriculture, Food processing, IgE, Arable land, business, Food Hypersensitivity
Abstract

Genetically modified (GM) plants are increasingly used for food production and industrial applications. As the global population has surpassed 7 billion and per capita consumption rises, food production is challenged by loss of arable land, changing weather patterns, and evolving plant pests and disease. Previous gains in quantity and quality relied on natural or artificial breeding, random mutagenesis, increased pesticide and fertilizer use, and improved farming techniques, all without a formal safety evaluation. However, the direct introduction of novel genes raised questions regarding safety that are being addressed by an evaluation process that considers potential increases in the allergenicity, toxicity, and nutrient availability of foods derived from the GM plants. Opinions vary regarding the adequacy of the assessment, but there is no documented proof of an adverse effect resulting from foods produced from GM plants. This review and opinion discusses current practices and new regulatory demands related to food safety.

Published
2011
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