1. Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors
- Author
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Didier M. Lambert, Coco N. Kapanda, and J. H. Poupaert
- Subjects
Pharmacology ,Chemistry, Pharmaceutical ,musculoskeletal, neural, and ocular physiology ,Organic Chemistry ,Biology ,Biochemistry ,Medicinal chemistry ,Endocannabinoid system ,Amidohydrolases ,Structure-Activity Relationship ,nervous system ,Drug Discovery ,Hydrolase ,Animals ,Humans ,Molecular Medicine ,lipids (amino acids, peptides, and proteins) ,Enzyme Inhibitors ,Endocannabinoids - Abstract
Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.
- Published
- 2013
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