1. The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest–Activity Patterns in Cancer Survivors
- Author
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Guillaume Y. Millet, Tristan Martin, S. Nicole Culos-Reed, Rosie Twomey, Mary E. Medysky, John Temesi, Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), University of Calgary, Motricité, interactions, performance EA 4334 / Movement - Interactions - Performance (MIP), Le Mans Université (UM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Université de Nantes (UN)-Université de Nantes (UN), University of Brighton, Oregon Health and Science University [Portland] (OHSU), University of Northumbria at Newcastle [United Kingdom], Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), Martin, Tristan, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), and Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Le Mans Université (UM)
- Subjects
insomnia ,[SDV]Life Sciences [q-bio] ,0302 clinical medicine ,Cancer Survivors ,Neoplasms ,Insomnia ,Medicine ,Cancer-related fatigue ,Fatigue ,RC254-282 ,ComputingMilieux_MISCELLANEOUS ,0303 health sciences ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Sleep in non-human animals ,humanities ,SportRxiv|Rehabilitation and Therapy|Medicine and Health ,3. Good health ,[SDV] Life Sciences [q-bio] ,bepress|Social and Behavioral Sciences|Sociology ,SportRxiv|Sport and Exercise Science ,030220 oncology & carcinogenesis ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,medicine.symptom ,Sleep onset ,[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] ,medicine.medical_specialty ,Rest ,bepress|Life Sciences|Kinesiology ,bepress|Medicine and Health Sciences|Rehabilitation and Therapy ,B100 ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Article ,03 medical and health sciences ,SportRxiv|Rehabilitation and Therapy ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Humans ,bepress|Medicine and Health Sciences|Rehabilitation and Therapy|Other Rehabilitation and Therapy ,SportRxiv|Rehabilitation and Therapy|Other Rehabilitation and Therapy ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,SportRxiv|Sport and Exercise Science|Physical Activity ,030304 developmental biology ,[SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT] ,business.industry ,Cancer ,Actigraphy ,cancer-related fatigue ,Rest activity ,medicine.disease ,C600 ,B900 ,Physical therapy ,rest–activity cycle ,Sleep onset latency ,Sleep ,business ,030217 neurology & neurosurgery ,actigraphy - Abstract
Cancer-related fatigue can continue long after curative cancer treatment. The aim of this study was to investigate sleep and rest–activity cycles in fatigued and non-fatigued cancer survivors. We hypothesized that sleep and rest–activity cycles would be more disturbed in people experiencing clinically-relevant fatigue, and that objective measures of sleep would be associated with the severity of fatigue in cancer survivors. Cancer survivors (n = 87) completed a 14-day wrist actigraphy measurement to estimate their sleep and rest–activity cycles. Fatigue was measured using the Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F). Participants were dichotomised into two groups using a previously validated score (fatigued n = 51 and non-fatigued n = 36). The participant’s perception of sleep was measured using the Insomnia Severity Index (ISI). FACIT-F score was correlated with wake after sleep onset (r = −0.28, p = 0.010), sleep efficiency (r = 0.26, p = 0.016), sleep onset latency (r = −0.31, p = 0.044) and Insomnia Severity Index (ISI) score (r = −0.56, p <, 0.001). The relative amplitude of the rest–activity cycles was lower in the fatigued vs. the non-fatigued group (p = 0.017, d = 0.58). After treatment for cancer, the severity of cancer-related fatigue is correlated with specific objective measures of sleep, and there is evidence of rest–activity cycle disruption in people experiencing clinically-relevant fatigue.
- Published
- 2021
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