1. Adenovirus vectors for gene expression
- Author
-
Robert J. Natuk, Satoshi Mizutani, Bruce B. Mason, Paul P. Hung, Michael D. Lubeck, Alan R. Davis, Bernard J. Selling, Murty Chengalvala, Ramesh A. Bhat, Pranab K. Chanda, Bheem M. Bhat, and Kuo-Hom Lee Hsu
- Subjects
Genetics ,Vaccines, Synthetic ,Genetic Vectors ,Biomedical Engineering ,Human immunodeficiency virus (HIV) ,Gene Expression ,Heterologous ,Bioengineering ,Genetic Therapy ,HSL and HSV ,Biology ,medicine.disease_cause ,Virology ,Adenoviridae ,Gene expression ,medicine ,Animals ,Humans ,Cloning, Molecular ,High level expression ,Gene ,Biotechnology - Abstract
Adenoviruses possess a combination of features that make them highly suitable as vectors for expression of heterologous genes. Non-conditional and non-defective adeno-vectors have been constructed to obtain high level expression of a number of foreign genes and some of them have been shown in animal models to exhibit excellent promise as vaccine candidates.
- Published
- 1991
- Full Text
- View/download PDF