1. Lumenal protein multimerization in the distal secretory pathway/secretory granules.
- Author
-
Arvan P, Zhang BY, Feng L, Liu M, and Kuliawat R
- Subjects
- Animals, Carrier Proteins metabolism, Cell Compartmentation, Cytoplasmic Granules ultrastructure, Humans, Intracellular Membranes metabolism, Models, Biological, Protein Precursors metabolism, Protein Processing, Post-Translational, Protein Transport, Solubility, trans-Golgi Network metabolism, Cytoplasmic Granules metabolism, Golgi Apparatus metabolism, Proteins metabolism
- Abstract
Differences in protein solubility appear to play an important role in lumenal protein trafficking through Golgi/post-Golgi compartments. Recent advances indicate that multimeric protein assembly is one of the factors regulating the efficiency of protein storage within secretory granules, by mechanisms that, with slight modification, might be considered to represent the culmination of a process of Golgi cisternal maturation.
- Published
- 2002
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