1. Regulation of the HNF-1 homeodomain proteins by DCoH
- Author
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Gerald R. Crabtree and Linda P. Hansen
- Subjects
Transcriptional Activation ,Transcription, Genetic ,Protein Conformation ,Recombinant Fusion Proteins ,Molecular Sequence Data ,Biology ,Models, Biological ,In vivo ,Genetics ,Animals ,Humans ,Hepatocyte Nuclear Factor 1-alpha ,Hydro-Lyases ,Hepatocyte Nuclear Factor 1-beta ,Transcriptional activity ,Base Sequence ,Nuclear Proteins ,DNA ,NKX-homeodomain factor ,Cell biology ,DNA-Binding Proteins ,Hepatocyte nuclear factors ,Gene Expression Regulation ,Hepatocyte Nuclear Factor 1 ,Homeobox ,Function (biology) ,Protein Binding ,Transcription Factors ,Developmental Biology - Abstract
The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which confers transcriptional activity to the hepatocyte nuclear factor 1 and provides a model of how other accessory factors might modulate the function of homeodomain proteins.
- Published
- 1993
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