1. Role of PD-1 in regulating acute infections
- Author
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Brown, Keturah E, Freeman, Gordon J, Wherry, E John, and Sharpe, Arlene H
- Subjects
- *
INFECTION , *T cells , *NATURAL immunity , *MACROPHAGES , *B cells , *IMMUNE response , *IMMUNOLOGY - Abstract
While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by ‘helpless’ CD8 memory T cells. An emerging role for PD-1 in innate immunity has been revealed by recent studies showing that PD-1 can limit function of DC and macrophages as well as T cell independent B cell responses. Thus, PD-1 can influence adaptive immune responses during acute infections, though precisely how this regulation occurs is only just beginning to be appreciated. [Copyright &y& Elsevier]
- Published
- 2010
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