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Tissue-resident memory CD8 + T cells (T RM ) are localized in non-lymphoid tissues throughout the body where they mediate long-lived protective immunity at common sites of pathogen exposure. As the signals controlling T RM differentiation are uncovered, it is becoming apparent that the dynamic activities of numerous transcription factors are intricately involved in T RM formation. Here, we highlight known transcriptional regulators of T RM differentiation and discuss how understanding the transcriptional programming of CD8 + T cell residency in non-lymphoid tissues can be leveraged to prevent or treat disease., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

NKT cells comprise a distinct T cell subset that acquires effector function during development and prior to antigen exposure. NKT cells are of limited antigen specificity but possess the ability to be recruited into an immune response without the need for further differentiation or proliferation and thus may be considered to function as memory cells or as part of the innate immune system. Although the development and maturation of NKT cells share some similarities with conventional T cell populations, many transcriptional regulators and signaling molecules are known to be uniquely required for NKT cell development. Recently, new transcription factors that specify NKT lineage and effector function and novel roles for previously identified transcriptional regulators in the differentiation of the NKT cell population have been discovered., (Copyright 2010 Elsevier Ltd. All rights reserved.)