1. Protein-protein interactions and human cellular cofactors as new targets for HIV therapy.
- Author
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Tintori C, Brai A, Fallacara AL, Fazi R, Schenone S, and Botta M
- Subjects
- Adaptor Proteins, Signal Transducing metabolism, Anti-HIV Agents pharmacology, Anti-HIV Agents therapeutic use, CD4 Antigens metabolism, DEAD-box RNA Helicases metabolism, HIV Envelope Protein gp120 metabolism, HIV Infections metabolism, HIV Integrase, Humans, Protein-Tyrosine Kinases metabolism, Receptors, CCR5 metabolism, Transcription Factors metabolism, HIV Infections drug therapy
- Abstract
Two novel approaches for the development of new drugs against AIDS are summarized each leading to the achievement of important discoveries in anti-HIV therapy. Despite the success of HAART in reducing mortality, resistant strains continue to emerge in the clinic, underscoring the importance of developing next-generation drugs. Protein-protein interactions and human cellular cofactors represent the new targets of tomorrow in HIV research. The most relevant results obtained in the last few years by the two new strategies are described herein., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Published
- 2014
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