1. Laboratory evolution of protein conformational dynamics
- Author
-
Peter D. Mabbitt, Galen J. Correy, Nobuhiko Tokuriki, Colin J. Jackson, Eleanor C Campbell, and Ashley M. Buckle
- Subjects
0301 basic medicine ,Computer science ,Protein Conformation ,Proteins ,Computational biology ,Protein engineering ,Molecular Dynamics Simulation ,Protein Engineering ,Evolution, Molecular ,03 medical and health sciences ,030104 developmental biology ,Protein structure ,Structural Biology ,Computer Simulation ,Evolutionary selection ,Molecular Biology ,Biophysical chemistry - Abstract
This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory based evolutionary selection. We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes. Finally, we offer some perspectives on the emerging view of conformational dynamics and evolution, and the challenges that we face in rationally engineering conformational dynamics.
- Published
- 2017