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Start Over Author "Xiaosheng Qu" Journal current pharmaceutical design
2 results on '"Xiaosheng Qu"'

1. Application of Machine Learning Methods for the Development of Antidiabetic Drugs

Author

Liu Xiujuan, Xiaosheng Qu, Sooranna Dev, Minjie Li, Bing Niu, Zhao Juanjuan, Pengcheng Xu, Xiaobo Ji, and Wencong Lu

Subjects
Pharmacology, Drug, Dipeptidyl-Peptidase IV Inhibitors, Dpp iv inhibitors, business.industry, Computer science, media_common.quotation_subject, Machine learning, computer.software_genre, Machine Learning, Diabetes Mellitus, Type 2, Drug development, Blueprint, Drug Discovery, Humans, Hypoglycemic Agents, Artificial intelligence, business, computer, media_common
Abstract

Diabetes is a chronic non-communicable disease caused by several different routes, which has attracted increasing attention. In order to speed up the development of new selective drugs, machine learning (ML) technology has been applied in the process of diabetes drug development and opens up a new blueprint for drug design. This review provides a comprehensive portrayal of the application of ML in antidiabetic drug use.

Published
2022

2. Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments

Author

Xiaoyu Xu, Wei Liu, Kaijun Li, Ruitong Song, Xiaosheng Qu, Jian-Feng He, Yi Du, and Meifeng Luo

Subjects
Pharmacology, Aquaporin 4, medicine.medical_specialty, Weakness, Neuromyelitis optica, business.industry, Central nervous system, Neuromyelitis Optica, Disease, medicine.disease, Dermatology, medicine.anatomical_structure, Spinal Cord, Drug Discovery, Optic nerve, Demyelinating disease, Medicine, Humans, Spectrum disorder, medicine.symptom, business, Autoantibodies
Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and disability rates are high. In the present work, we review recent advances in the diagnosis and treatment of patients with NMOSD, as well as the pathogenesis and mechanisms of AQP4-IgG-seropositive NMOSD.

Published
2020

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