1. Association between gut microbiota and prediabetes in people living with HIV
- Author
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Kulapong Jayanama, Angsana Phuphuakrat, Pisut Pongchaikul, Pinidphon Prombutara, Hataikarn Nimitphong, Sirimon Reutrakul, and Somnuek Sungkanuparph
- Subjects
Gut microbiota ,HIV ,People living with HIV ,Plasma glucose ,Prediabetes ,Microbiology ,QR1-502 ,Genetics ,QH426-470 - Abstract
The prevalence of prediabetes is rapidly increasing in general population and in people living with HIV (PLWH). Gut microbiota play an important role in human health, and dysbiosis is associated with metabolic disorders and HIV infection. Here, we aimed to evaluate the association between gut microbiota and prediabetes in PLWH. A cross-sectional study enrolled 40 PLWH who were receiving antiretroviral therapy and had an undetectable plasma viral load. Twenty participants had prediabetes, and 20 were normoglycemic. Fecal samples were collected from all participants. The gut microbiome profiles were analyzed using 16S rRNA sequencing. Alpha-diversity was significantly lower in PLWH with prediabetes than in those with normoglycemia (p
- Published
- 2022
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