1. Allyl isothiocyanate attenuates LED light-induced retinal damage in rats: exploration for the potential molecular mechanisms
- Author
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Mehmet Tuzcu, Nurhan Sahin, Ibrahim Hanifi Ozercan, Kazim Sahin, Abhijeet Morde, Hasan Gencoglu, Cemal Orhan, and Muralidhara Padigaru
- Subjects
Male ,Antioxidant ,medicine.medical_treatment ,Apoptosis ,macromolecular substances ,Toxicology ,medicine.disease_cause ,Protective Agents ,Retina ,chemistry.chemical_compound ,Nutritional Interventions ,Isothiocyanates ,medicine ,Animals ,Humans ,Lighting ,Light Pollution ,Artificial light ,Retinal damage ,Retinal Degeneration ,Retinal ,General Medicine ,Allyl isothiocyanate ,Mitochondria ,Rats ,Disease Models, Animal ,Oxidative Stress ,chemistry ,Semiconductors ,Biophysics ,Light induced ,Oxidative stress - Abstract
Environmental light pollution due to artificial light may increase the rate and severity of retinal diseases, and plant-based nutritional interventions with antioxidant properties have the potential to reverse this phenomenon. We aimed to investigate the potential effects of allyl isothiocyanate (AITC) against white light-emitting diode (LED)-induced retinal degeneration (RD) in the rats.Twenty-eight male rats were allocated as: (i) Control, (ii) LED, (iii) LED + AITC (10 mg/kg BW), (iv) LED + AITC (20 mg/kg BW). Rats were administered with AITC for 28 days, followed by two days of intense environmental LED light (750AITC lowered the serum and retina malondialdehyde (MDA) levels while significantly (In conclusion, four weeks of AITC administration to the rats showed specific protective effects against two days of intense LED light-induced retinal damage; through antiinflammatory, antioxidant, anti-apoptotic, and modulating mitochondrial metabolic pathways.
- Published
- 2021