1. CD40L-expressing CD4
- Author
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Joelle, Dulong, Séverine, Loisel, Delphine, Rossille, Simon, Léonard, Nadège, Bescher, Isabelle, Bezier, Maelle, Latour, Céline, Monvoisin, Delphine, Monnier, Nicolas, Bertheuil, David, Roulois, and Karin, Tarte
- Subjects
CD4-Positive T-Lymphocytes ,Adipose Tissue ,Tumor Necrosis Factor-alpha ,T-Lymphocytes ,CD40 Ligand ,Interleukin-8 ,NF-kappa B ,Humans ,Obesity ,Chemokines ,Stromal Cells ,Cells, Cultured - Abstract
The therapeutic potential of culture-adapted adipose-derived stromal cells (ASCs) is largely related to their production of immunosuppressive factors that are inducible in vitro by priming with inflammatory stimuli, in particular tumor necrosis factor-α (TNFα) and interferon-γ (IFNγ). In vivo, obesity is associated with chronic inflammation of white adipose tissue, including accumulation of neutrophils, infiltration by IFNγ/TNFα-producing immune cells, and ASC dysfunction. In the current study, we identified in obese patients a simultaneous upregulation of CD40Lin the adipose tissue stroma vascular fraction (AT-SVF), correlated with the Th1 gene signature, and an overexpression of CD40 by native ASCs. Moreover, activated CD4
- Published
- 2021