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Start Over Author "Boris Kysela" Journal dalton transactions (cambridge, england : 2003)
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1. Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

Author

Alexandra. J. Pope, Boris Kysela, Christopher K. Bruce, and Michael J. Hannon

Subjects
Chemistry, Non covalent, Iron, In vitro cytotoxicity, Antineoplastic Agents, DNA, Molecular biology, Incubation period, Inorganic Chemistry, Drug compound, chemistry.chemical_compound, Absolute amount, Biochemistry, Coordination Complexes, Cell Line, Tumor, Cytotoxicity testing, Humans, Imines
Abstract

Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.

Published
2010

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