1. Data set on a study of gene expression in peripheral samples to identify biomarkers of severity of allergic and nonallergic asthma
- Author
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David Calzada, Joaquín Quiralte, Joaquín Sastre, Fernando Florido, Selene Baos, Blanca Cárdaba, Carlos Lahoz, Lucía Cremades, [Baos,S, Calzada,D, Cremades,L, Lahoz,C, Cárdaba,B] Immunology Department, IIS- Jiménez Díaz Foundation, UAM, Madrid, Spain. [Baos,S, Sastre,J, Cárdaba,B] CIBERES, CIBER of Respiratory Diseases, Spain. [Sastre,J] Allergy Department, Jiménez Díaz Foundation, Madrid, Spain. [Quiralte,J] Allergy Department, Vírgen del Rocío University Hospital, Seville, Spain. [Florido,F] Allergy Department, San Cecilio University Hospital, Granada, Spain., [Baos, Selene] UAM, IIS Jimenez Diaz Fdn, Immunol Dept, Madrid, Spain, [Calzada, David] UAM, IIS Jimenez Diaz Fdn, Immunol Dept, Madrid, Spain, [Cremades, Lucia] UAM, IIS Jimenez Diaz Fdn, Immunol Dept, Madrid, Spain, [Lahoz, Carlos] UAM, IIS Jimenez Diaz Fdn, Immunol Dept, Madrid, Spain, [Cardaba, Blanca] UAM, IIS Jimenez Diaz Fdn, Immunol Dept, Madrid, Spain, [Sastre, Joaquin] CIBERES, CIBER Resp Dis, Madrid, Spain, [Lahoz, Carlos] CIBERES, CIBER Resp Dis, Madrid, Spain, [Cardaba, Blanca] CIBERES, CIBER Resp Dis, Madrid, Spain, [Sastre, Joaquin] Jimenez Diaz Fdn, Allergy Dept, Madrid, Spain, [Quiralte, Joaquin] Virgen del Rocio Univ Hosp, Allergy Dept, Seville, Spain, [Florido, Fernando] San Cecilio Univ Hosp, Allergy Dept, Granada, Spain, FEDER, CIBERES (ISCIII), Biobank from the Fund for Health Research (Spanish Ministry of Economy and Competitiveness), Conchita Rabago Foundation, MINECO, European Social Fund (ESF), and Youth Employment Initiative (YEI)
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0301 basic medicine ,Allergy ,Diseases::Respiratory Tract Diseases::Bronchial Diseases::Asthma [Medical Subject Headings] ,Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings] ,Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Proteomics [Medical Subject Headings] ,Leucocitos mononucleares ,Sistema mononuclear fagocítico ,lcsh:Computer applications to medicine. Medical informatics ,Peripheral blood mononuclear cell ,MSR1 ,03 medical and health sciences ,0302 clinical medicine ,Gene expression ,Chemicals and Drugs::Biological Factors::Biological Markers [Medical Subject Headings] ,medicine ,Receptores depuradores ,lcsh:Science (General) ,Gene ,Asma ,Anatomy::Hemic and Immune Systems::Immune System::Mononuclear Phagocyte System [Medical Subject Headings] ,Data Article ,Asthma ,Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Scavenger [Medical Subject Headings] ,Multidisciplinary ,business.industry ,Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear [Medical Subject Headings] ,medicine.disease ,Phenotype ,Biomarcadores ,Proteómica ,030104 developmental biology ,Immunology ,Peripheral samples ,lcsh:R858-859.7 ,Population study ,business ,Biomarkers ,lcsh:Q1-390 ,030215 immunology - Abstract
This article contains information related to the research article entitled "Biomarkers associated with disease severity in allergic and nonallergic asthma" (S. Baos, D. Calzada, L. Cremades, J. Sastre, J. Quiralte, F. Florido, C. Lahoz, B. Cárdaba, In press). Specifically, the clinical criteria stablished for selecting the study population (n=104 subjects) are described. Moreover, this article describes the criteria for selecting the 94 genes to be analyzed in PBMCs (peripheral blood mononuclear cells), it is provided a description of these genes and a Table with the genes most differentially expressed by clinical phenotypes and, finally it is detailed the experimental methodology followed for studying the protein expression of MSR1 (macrophage scavenger receptor 1), one of the genes evaluated in the research. This work was supported in part by research grants PI13/01730 co-supported by FEDER, CIBERES (ISCIII, 0013) and Biobank (PT13/0010/0012) from the Fund for Health Research (Spanish Ministry of Economy and Competitiveness). S. Baos was supported by CIBERES (ISCIII, 0013) and Conchita Rábago Foundation. D. Calzada by Conchita Rábago Foundation, Madrid, Spain. L. Cremades was supported by a contract from MINECO (PEJ-2014-A-31609, Sistema de Garantía Juvenil), cofinanced by European Social Fund (ESF) and Youth Employment Initiative (YEI). Yes
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- 2017
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