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Objective The aim of this study was to incorporate sol–gel-derived bioactive glass as filler into experimental adhesive resins and evaluate the influence of glass composition on the physicochemical and biological properties of the developed adhesives. Materials and methods Sol–gel particles were produced with or without the addition of niobium (BAGNb or BAG, respectively). The produced particles were incorporated (2 wt%) into experimental adhesive resins formulated with 66 wt% bisphenol A-glycidyl methacrylate and 33 wt% hydroxyethyl methacrylate. Ethyl dimethyl-4-aminobenzoate and camphorquinone were used as photoinitiator system. Two experimental groups were produced: ABAGNb and ABAG. The adhesive without particles was used as control (ACG). The materials were tested for their degree of conversion, softening in solvent, and cytotoxicity. The mineral deposition was analyzed by Raman spectroscopy. Flexural strength and immediate and 1-year microtensile bond strength were evaluated. Results No statistical difference was found in degree of conversion. ABAGNb showed reduced softening and higher mineral deposition than ACG and ABAG after 28 days. ABAG and ABAGNb resulted in higher cell viability and lower flexural strength when compared to ACG. After 1-year, ABAGNb and ABAG presented statistically significant lower μTBS values. Significance Sol–gel-derived bioactive glasses promoted increased mineral deposition and cell viability for experimental adhesives with increased phosphate content and longitudinal μTBS values for the ABAGNb group. These results suggest the potential of the studied particles to be applied as bioactive fillers for dental adhesives. Reductions in longitudinal μTBS and flexural strength, however, were observed for both glasses compositions and must be considered.

Objective The aim of this study is to produce sol-gel derived calcium silicate particles (CS) and evaluate the influence of different concentration of calcium tungstate in the physical, chemical, mechanical and biological properties of developed cements. Methods Sol-gel route were used to synthesize calcium silicate particles that were characterized with x-ray difraction, Fourier transformed infrared spectroscopy, scanning electron microscopy, laser diffraction and nitrogen absorption. Cements were formulated with the addition of different concentrations of calcium tungstate (CaWO4), resulting in four experimental groups according to the CS:CaWO4 ratio: CS100 (100:0), CS90 (90:10), CS80 (80:20), CS70 (70:30). The setting time, radiopacity, compressive strength, pH, calcium release, cell proliferation and cell differentiation were used to characterize the cements. Results CS particles were succesfully sinthesized. The addition of CaWO4 increased the radiopacity and did not influenced the setting time and the mechanical properties of cements. The pH of distilled water was increased for all groups and the CS100 and CS90 groups presented incresed calcium release. Reduced cell viability was found for CS70 while CS100 and CS90 presented higher ALP activity and % of mineralized nodules after 21 days. Significance Sol-gel derived CS particles were sucssfully developed with potential to applied for the production of bioactive ceramic cements. The addition of 10% of CaWO4 resulted in cements with adequate properties and bioactivity being an alternative for regenerative endodontic treatments.