1. [Predictive parameters in children with biliary atresia]
- Author
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J, Leonhardt, J F, Kuebler, C, Turowski, R, von Wasielewski, E D, Pfister, T, Becker, B M, Ure, and C, Petersen
- Subjects
Male ,Adolescent ,Liver Cirrhosis, Biliary ,Infant, Newborn ,Infant ,Alanine Transaminase ,Bilirubin ,Portoenterostomy, Hepatic ,gamma-Glutamyltransferase ,Prognosis ,Survival Analysis ,Young Adult ,Liver ,Liver Function Tests ,Biliary Atresia ,Predictive Value of Tests ,Child, Preschool ,Disease Progression ,Humans ,Female ,Child ,Biomarkers ,Follow-Up Studies ,Retrospective Studies - Abstract
Most children with biliary atresia require liver transplantation, and only about 20% survive in the long term with their native livers. Prognostic factors that determine disease progression are still lacking. This retrospective survey of 85 BA patients from 1993 to 2003 was aimed to evaluate prognostic factors using the log rank test. After 5 years 40% of the patients are alive with their native livers (35/85), 26 of them with normal bilirubin (31%). Age at Kasai operation (P=0.46), degree of liver fibrosis (P=0.95), and all laboratory test results before Kasai failed to correlate with outcome. Normal levels of bilirubin 3, 6, and 12 months after Kasai and of aspartate aminotransferase with gammaGT after 6 months are associated with survival with native liver. In conclusion our data demonstrate that a lack of predictive factors must prevent primary liver transplantation in BA patients.
- Published
- 2009