1. A study of the safety and efficacy of calcipotriol and betamethasone dipropionate scalp formulation in the long-term management of scalp psoriasis.
- Author
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Luger TA, Cambazard F, Larsen FG, Bourcier M, Gupta G, Clonier F, Kidson P, and Shear NH
- Subjects
- Administration, Cutaneous, Adolescent, Adult, Aged, Aged, 80 and over, Anti-Inflammatory Agents adverse effects, Betamethasone adverse effects, Betamethasone therapeutic use, Calcitriol adverse effects, Calcitriol therapeutic use, Canada, Denmark, Dermatologic Agents adverse effects, Double-Blind Method, Drug Combinations, Female, France, Germany, Humans, Male, Middle Aged, Ointments, Pharmaceutical Vehicles, Prospective Studies, Severity of Illness Index, Treatment Outcome, United Kingdom, Anti-Inflammatory Agents therapeutic use, Betamethasone analogs & derivatives, Calcitriol analogs & derivatives, Dermatologic Agents therapeutic use, Psoriasis drug therapy, Scalp
- Abstract
Background: Effective and safe products are needed for long-term management of scalp psoriasis. This study investigated the long-term safety and efficacy of a two-compound formulation (calcipotriol 50 microg/g plus betamethasone dipropionate 0.5 mg/g) for scalp psoriasis., Methods: In this 52-week, international, double-blind study, 869 patients with moderate-to-severe scalp psoriasis were randomized to either a two-compound scalp formulation (n = 429) or calcipotriol (n = 440)., Results: Adverse drug reactions were less frequent in the two-compound group compared with the calcipotriol group (17.2 vs. 29.5%; p < 0.001). Incidences of adverse events possibly associated with long-term corticosteroid use were low in both the two-compound (2.6%) and the calcipotriol (3.0%) groups. Disease was satisfactorily controlled in 92.3% of visits in the two-compound group versus 80.0% in the calcipotriol group (p < 0.001)., Conclusion: The two-compound scalp formulation demonstrated a high level of safety and efficacy in long-term management of scalp psoriasis., (2008 S. Karger AG, Basel.)
- Published
- 2008
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