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FROM ELDERDERM 2024 WASHINGTON--The chronic, excessive fragility of aging and sun-damaged skin has a name in the medical literature: dermatoporosis. This identification is helpful because it validates patients' suffering and [...]

WASHINGTON -- In 2013, Vishal A. Patel, MD, was completing a fellowship in Mohs surgery and cutaneous oncology at Columbia University Medical Center, New York City, when a study was [...]

Patients with psoriatic disease have significantly higher risks of myocardial infarction, stroke, and cardiovascular mortality than does the general population, yet research consistently paints what dermatologist Joel M. Gelfand, MD, [...]

WASHINGTON, DC -- Cutaneous immune related adverse events (cirAEs) in oncology patients receiving immune checkpoint inhibitors (ICIs) should be treated in as targeted a fashion as possible and with judicious [...]

WASHINGTON -- Immunoglobulin E (IgE) and eosinophils appeared to be reliable biomarkers of type 2 inflammation in chronic pruritus of unknown origin (CPUO) and predictors of a positive response to [...]

FROM ELDERDERM 2024 WASHINGTON--The onset of atopic dermatitis (AD) in older adulthood --even in adults aged [greater than or equal to] 90 years--is a phenomenon documented in the literature in [...]

WASHINGTON -- Atopic dermatitis (AD) in childhood presents most commonly by age 1 and typically begins on the face and, while it can make infants 'miserable,' caregiver and provider concerns [...]

A REVIEW of the literature on climate change and atopic dermatitis (AD) found evidence of a broad and negative impact of climatic hazards on various aspects of AD, including prevalence, [...]

Dietary supplements have a role in the integrative treatment of vitiligo, largely through antioxidant pathways and as an adjuvant to phototherapy, Ammar Ahmed, MD, associate professor of dermatology at Dell [...]

FROM JAMA DERMATOLOGY SPIRONOLACTONE was not associated with any meaningful increase in the risk of breast cancer or other solid-organ cancers in a systematic review and meta-analysis covering seven observational [...]

Isotretinoin was not associated with a 1-year risk of incident inflammatory bowel disease in a large population-based cohort study that also found no significant association of oral tetracycline-class antibiotics with [...]

WASHINGTON -- Multiple biologic failure in a minority of patients with psoriasis may have several causes, from genetic endotypes and immunologic factors to lower serum drug levels, the presence of [...]

WASHINGTON -- A series of three higher-than-approved induction doses of the interleukin-23 inhibitor risankizumab in patients with psoriasis--and no further subsequent dosing--led to an 'unprecedented' level of complete skin clearance [...]

WASHINGTON -- What does shared decision-making about atopic dermatitis (AD) treatment mean at a time of increasing treatment options and patient concerns about drug safety and the potentially lifelong need [...]

WASHINGTON -- The approval of the interleukin (ID36 receptor antagonist spesolimab for treating generalized pustular psoriasis flares in 2022 brightened the treatment landscape for this rare condition, and a recently [...]

Ateledermatology clinic program established in Ward 8 of Washington to help residents learn about and initiate care for atopic dermatitis (AD) has garnered high patient satisfaction marks and may serve [...]

WASHINGTON -- Lebrikizumab, an interleukin (IL)-13 inhibitor under investigation for adults and adolescents with moderate to severe atopic dermatitis (AD), was efficacious in improving facial and hand dermatitis in a [...]

Children with atopic dermatitis (AD) were significantly more likely to have positive patch test results than were children without AD, according to a study of over 900 children evaluated for [...]

WASHINGTON -- A substantial proportion of adults with moderate to severe atopic dermatitis (AD) treated with oral abrocitinib 100 mg or 200 mg once daily for up to 96 weeks [...]

Climate change will increasingly affect the distribution and frequency of insect-borne diseases, cutaneous leishmaniasis, skin cancer, fungal diseases, and a host of other illnesses that have cutaneous manifestations or involve [...]

A new drug application for a first-in-class photodynamic therapy (PDT) for treating early-stage cutaneous T-cell lymphoma (CTCL) has been submitted to the Food and Drug Administration based on phase 3 [...]

Stephanie Flores-Pollack, MD, a dermatology resident at the University of Pennsylvania, Philadelphia, began considering the field of dermatology when, as part of the Latino Medical Students Association, she was invited [...]

Peter A. Lio, MD, is a big user of the 'big guns' for his patients with atopic dermatitis (AD)--biologies, conventional immunosuppressants, and Janus kinase (JAK) inhibitors. But he also has [...]

A commentary published across four dermatology journals in September urges dermatologists and their medical societies to 'engage more meaningfully' on climate change issues, 'moving beyond merely discussing skin-related impacts' and [...]

For much of the past 50 years, many of the drugs used in dermatology have been adopted --and often adapted--from other specialties and used for dermatologic conditions. 'Almost every drug [...]

High-dose vitamin D led to improvement of toxic erythema of chemotherapy (TEC) within 1-4 days in a retrospective case series of six patients seen on an inpatient dermatology consultative service. [...]

A TOPICAL GEL that contains birch bark extract as the active ingredient--Filsuvez (Oleogel-S10)--has been recommended for approval for the treatment of partial-thickness wounds associated with dystrophic and junctional epidermolysis bullosa [...]

AN INVESTIGATIVE SYNTHETIC cannabinoid receptor type 2 (CB2) agonist, lenabasum, was associated with greater improvements than placebo in patients with skin-predominant dermatomyositis--some of it statistically significant--in a phase 2, double-blind, [...]

Global climate change is hitting home for dermatologists, according to a recent survey in which the majority of participants said their patients are already being impacted. Almost 80% of the [...]

A dermatologist-led model of cardiovascular disease (CVD) risk management for patients with psoriatic disease--in which dermatologists do more than refer patients to a primary care physician (PCP) or a cardiologist [...]

Dermatologists spent less time with Asian patients with psoriasis than patients of other races and ethnicities in a cross-sectional study using data from the National Ambulatory Medical Care Survey (NAMCS) [...]

Treatment with the humanized monoclonal antibody litifilimab improved scores on a validated measure of skin disease activity in an international phase 2 trial of patients with cutaneous lupus erythematosus (CLE). [...]

BLACK AND HISPANIC patients had higher inpatient care utilization for mycosis fungoides (MF)--and were admitted at a younger age --compared with White patients, according to an analysis of the 2012-2017 [...]

Intravenous gentamicin therapy was associated with new laminin 332--a major component of anchoring filaments in the dermal-epidermal junction--in the skin of five pediatric patients with intermediate or severe junctional epidermolysis [...]

A cluster analysis of circulating plasma biomarkers in prurigo nodularis (PN) has identified two disease endotypes with inflammatory and noninflammatory biomarker profiles. The findings confirm clinical observations of disease heterogeneity, [...]

Black patients hospitalized with skin and soft-tissue infections were more likely to receive clindamycin and less likely to receive cefazolin--the latter of which is considered a first-line SSTI treatment--in a [...]

Christina Chambers, PhD, MPH, who runs the MotherToBaby Pregnancy Studies research center at the University of California, San Diego, has found most pregnant women to be 'entirely altruistic' about sharing [...]

Hair follicle miniaturization was a prominent feature of persistent chemotherapy-induced alopecia (pCLA) in breast cancer survivors who presented to four specialty hair clinics, and treatment with minoxidil (sometimes with antiandrogen [...]

Patients of skin of color (SOC) with bullous pemphigoid presented significantly more often with dyspigmentation than did White patients in a retrospective observational study of patients diagnosed with BP at [...]

A short-term Western diet facilitated the development of interleukin (IL)-23-mediated psoriasislike skin and joint inflammation and caused shifts in the intestinal microbiota in a murine model--findings that both reaffirm the [...]

Inpatient care utilization for hidradenitis suppurativa (HS) was higher for Black and Hispanic patients, compared with White patients, in an analysis of the 2012-2017 National Inpatient Sample. The differences occurred [...]

BLACK PATIENTS diagnosed by dermatologists with cutaneous sarcoidosis were significantly more likely to have unrecognized systemic organ involvement than were non-Black patients, according to a retrospective chart review of patients [...]

ASIAN AMERICANS with melanoma presented at a younger age but with higher rates of invasive disease and at later stages of disease, compared with non-Hispanic Whites, according to a secondary [...]

Patients with vitiligo have faced significant impacts psychosocially and in many cases, profound losses of identity--and they've had only minimal success with treatment, according to participants who spoke at and [...]

FROM NATURE MEDICINE Skin microbiome therapy to protect against Staphylococcus aureus in patients with atopic dermatitis (AD) proved safe in a phase 1 randomized clinical trial that also demonstrated 'encouraging [...]

The article focuses on the complexities of multiple biologic failures in psoriasis and psoriatic arthritis (PsA), delving into various causes including genetic factors, immunologic elements, lower drug levels, gender differences, and associated comorbidities. Topics include declining effectiveness of biologics over time, genetic endotypes impacting treatment responses, variables influencing multiple biologic failures, and the impact of comorbidities on treatment outcomes in psoriasis and PsA.

The article focuses on the challenges in treating palmoplantar pustulosis and other acral psoriatic diseases, highlighting treatment efficacy and the struggle to find effective therapeutic options. Topics include the disparity in treatment responses between acral and non-acral psoriasis, the modest efficacy of available treatments for palmoplantar pustulosis, and ongoing research efforts to understand the immunological differences and identify potential novel therapies for these conditions.

The article focuses on the potential role of dietary supplements in managing vitiligo, discussing their impact on oxidative pathways and as adjuncts to phototherapy. Topics include recommended supplements like Ginkgo biloba, vitamins C and E, and alpha-lipoic acid, studies highlighting their potential effectiveness, and the need for larger, higher-quality trials to further understand their efficacy in vitiligo treatment.

The article focuses on psoriatic disease, particularly psoriatic arthritis (PsA), and the need for a diagnostic test and targeted treatments. It mentions researchers are working to better understand the underlying mechanisms and cellular interactions that lead to PsA, with efforts to define the transition from cutaneous psoriasis to PsA and develop a diagnostic test for early diagnosis.

The article focuses on a pilot study that explored the use of higher-than-approved induction doses of the interleukin-23 inhibitor risankizumab in patients with psoriasis to achieve long-term remission. It mentions the study found that a series of these high-dose treatments led to a significant level of complete skin clearance at week 52, suggesting a potential breakthrough in psoriasis treatment by targeting resident memory T cells dependent on IL-23.