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Abstract Experiments and Computational Fluid Dynamics (CFD) simulations were performed to investigate the colloidal fouling control of a vibration enhanced reverse osmosis (VERO) membrane system for up to 12 h of operation time. A porous cake mass transfer model for the reverse osmosis (RO) colloidal fouling analysis was derived by combining the cake filtration model, cake enhanced osmotic pressure (CEOP) effect, the critical flux theory, and the solute convection-diffusion model. The process of colloidal particle deposition and fouling formation on the membrane surface were visualized using this model. The permeate flux variation and cake layer distribution along the membrane were depicted. Systematic studies including different initial permeate fluxes, Reynolds numbers, particle concentrations, and vibration frequencies were carried out to investigate the system performance under different operation conditions. The results suggest that colloidal fouling induced permeate flux decline could be improved by the high-frequency vibration in the VERO module. Both simulations and experiments demonstrated that, with a fixed vibration amplitude, membrane module with higher vibration frequencies will have less NaCl accumulation and higher permeate flux under the influence of colloidal fouling. Highlights • The colloidal fouling control performance of the vibration enhanced reverse osmosis technique was investigated. • A cell-based numerical model to analyze the process of membrane colloidal fouling was developed and validated by experiments. • Axial variations of the permeate flux and fouling cake height, the CEOP effect, and critical flux theory were considered. • Membrane colloidal fouling is significantly reduced by the proposed technique based on CFD simulations and experiments. [ABSTRACT FROM AUTHOR]