1. LEUNIG and SEUSS co-repressors regulate miR172 expression in Arabidopsis flowers
- Author
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Boyana Grigorova, Chloe Mara, Paja Sijacic, Courtney A. Hollender, Xuemei Chen, and Zhongchi Liu
- Subjects
Homeodomain Proteins ,Research Report ,Regulation of gene expression ,Genetics ,Co-Repressor Proteins ,biology ,Arabidopsis Proteins ,Apetala 2 ,fungi ,Arabidopsis ,Nuclear Proteins ,food and beverages ,Flowers ,biology.organism_classification ,MicroRNAs ,Gene Expression Regulation, Plant ,Transcriptional regulation ,Arabidopsis thaliana ,Molecular Biology ,Transcription factor ,Gene ,Transcription Factors ,Developmental Biology - Abstract
Central to the ABCE model of flower development is the antagonistic interaction between class A and class C genes. The molecular mechanisms underlying the A-C antagonism are not completely understood. In Arabidopsis thaliana, miR172 is expressed in the inner floral whorls where it downregulates the class A gene APETALA 2 (AP2). However, what controls this predominantly inner whorl-specific expression of miR172 is not known. We show that the LEUNIG (LUG) and SEUSS (SEU) co-repressors repress miR172 expression in the outer whorls of A. thaliana flowers. The recruitment of LUG/SEU to the miR172 promoters is dependent on AP2, suggesting that AP2 represses the expression of its cognate microRNA. Our study provides new insights into the molecular mechanisms underlying the A-C antagonism and shed light on the transcriptional regulation of miR172 during flower development.
- Published
- 2011
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