1. Cyclical fate restriction: a new view of neural crest cell fate specification
- Author
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Vsevolod J. Makeev, Robert N. Kelsh, Karen Camargo Sosa, Saeed Farjami, Andrea Rocco, and Jonathan H.P. Dawes
- Subjects
Epithelial-Mesenchymal Transition ,Pigment cell ,Pigmentation ,Gene Expression Regulation, Developmental ,Neural crest cell fate specification ,Cell Differentiation ,Biology ,Zebrafish Proteins ,Fate specification ,Melanocyte ,Neural Crest ,Animals ,Melanocytes ,Cell Lineage ,Neuroscience ,Molecular Biology ,Neural crest cell ,Zebrafish ,Developmental Biology - Abstract
Neural crest cells are crucial in development, not least because of their remarkable multipotency. Early findings stimulated two hypotheses for how fate specification and commitment from fully multipotent neural crest cells might occur, progressive fate restriction (PFR) and direct fate restriction, differing in whether partially restricted intermediates were involved. Initially hotly debated, they remain unreconciled, although PFR has become favoured. However, testing of a PFR hypothesis of zebrafish pigment cell development refutes this view. We propose a novel ‘cyclical fate restriction’ hypothesis, based upon a more dynamic view of transcriptional states, reconciling the experimental evidence underpinning the traditional hypotheses.
- Published
- 2022
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