1. Transient expression of c-fos during the development of the rat cerebral cortex
- Author
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Isabel de Diego, Britt Mellström, Alfonso Fairén, JoséR. Naranjo, and Carmen González-Martín
- Subjects
Cerebral Cortex ,animal structures ,Immunocytochemistry ,Central nervous system ,Gene Expression ,Rats, Inbred Strains ,Biology ,Embryonic stem cell ,c-Fos ,FOS Protein ,Rats ,medicine.anatomical_structure ,Developmental Neuroscience ,Cerebral cortex ,Proto-Oncogene Proteins ,Gene expression ,medicine ,biology.protein ,Animals ,Proto-Oncogene Proteins c-fos ,Neuroscience ,Immunostaining ,Developmental Biology - Abstract
The present study has explored with immunocytochemical methods the expression of the proto-oncogene c-fos during the pre- and postnatal development of the cerebral cortex of the rat. The immunostaining of the Fos protein follows a strikingly precise spatiotemporal pattern: it occurs uniquely within layer VIb of the developing cerebral cortex, and is transient, lasting only from embryonic day 20 until postnatal day 1. The expression of c-fos in layer VIb may be related to the dynamic changes that occur at this level during development.
- Published
- 1991
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