1. Polymorphism of ERK/PTPRR Genes in Major Depressive Disorder at Resting-State Brain Function.
- Author
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Wang, Yanfang, Li, Lusha, Xu, Cheng, Cao, Xiaohua, Liu, Zhifen, Sun, Ning, Zhang, Aixia, Li, Xinrong, and Zhang, Kerang
- Subjects
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MENTAL depression genetics , *GENETIC polymorphisms , *REST , *BRAIN imaging , *BRAIN physiology , *PSYCHOLOGY , *BRAIN , *BRAIN mapping , *CELLULAR signal transduction , *MENTAL depression , *MAGNETIC resonance imaging , *PHOSPHATASES , *CASE-control method - Abstract
The polymorphism of ERK and PTPRR in MDD is rarely reported. The present study investigated the association between the polymorphism of ERK/PTPRR and MDD at resting-state brain function using genomic imaging. It indicated that the amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) in functional magnetic resonance imaging (fMRI) changed significantly in various brain regions of MDD patients. The T/G allele of ERK-rs1267842 and G/C allele of PTPRR-rs1513105 showed abnormal ALFF and ReHo changes in cortex including superior frontal gyrus and middle temporal gyrus. The development of MDD may be related with the polymorphism of ERK-rs12678428 and PTPRR-rs1513105. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
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