1. Executive Response Monitoring and Inhibitory Control in Children With Phenylketonuria: Effects of Expectancy
- Author
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Carla Coleman, Shawn E. Christ, Evonne Timmerman, Desirée A. White, Dorothy K. Grange, Gabriel C. Araujo, and Robert D. Steiner
- Subjects
Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Phenylalanine ,Decision Making ,Intention ,Neuropsychological Tests ,Executive Function ,Phenylketonurias ,Inhibitory control ,Reaction Time ,Developmental and Educational Psychology ,medicine ,Humans ,Phenylalanine level ,Child ,Psychiatry ,Expectancy theory ,Extramural ,Age Factors ,nutritional and metabolic diseases ,Inhibition, Psychological ,Neuropsychology and Physiological Psychology ,Regression Analysis ,Female ,Cognition Disorders ,Psychology ,Phenylalanine metabolism - Abstract
Response monitoring (post-error slowing) and inhibitory control (commission errors) were examined in children with phenylketonuria (PKU) and controls (6-18 years) using Go/No-Go tasks with higher (PKU n = 37; control n = 55) versus lower (PKU n = 24; control n = 25) non-target expectancy. On both tasks children with PKU exhibited impaired monitoring and inhibitory control, but the post-error slowing pattern was different. With higher expectancy children with PKU slowed more (less efficient monitoring) and with lower expectancy slowed less (less monitoring) than controls. No effects of age or phenylalanine level were noted. These results indicate that expectancy differentially effects monitoring and inhibitory control in PKU.
- Published
- 2013
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