1. BDNF control of adult SVZ neurogenesis
- Author
-
Kevin G. Bath, Michael R. Akins, and Francis S. Lee
- Subjects
Neurogenesis ,Subventricular zone ,Tropomyosin receptor kinase B ,Article ,Cerebral Ventricles ,Behavioral Neuroscience ,Developmental Neuroscience ,Neurotrophic factors ,Developmental and Educational Psychology ,medicine ,Animals ,Brain-derived neurotrophic factor ,Neurons ,biology ,Mechanism (biology) ,Brain-Derived Neurotrophic Factor ,Brain ,Olfactory bulb ,medicine.anatomical_structure ,nervous system ,biology.protein ,Psychology ,Neuroscience ,Developmental Biology ,Neurotrophin - Abstract
The sensory processing of odorants is a dynamic process that requires plasticity at multiple levels. In the olfactory bulb (OB), inhibitory interneurons undergo lifelong replacement through a process known as adult neurogenesis. These newly born cells are incorporated in a learning-dependent fashion, a process which has led some to suggest this as a primary mechanism through which the OB retains a high degree of plasticity throughout life. A continued focus of researchers in this field has been to understand the molecular mechanisms controlling adult subventricular zone (SVZ) neurogenesis and the innate functional role of these cells. Brain-derived neurotrophic factor (BDNF) has been identified as a strong candidate molecule regulating adult OB neurogenesis. We review what is known regarding the functional role of newly-born cells, highlight the role of BDNF in this process, and describe preliminary findings from our lab implicating BDNF in the process of selecting of newly born cells for survival.
- Published
- 2010