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12 results on '"Evans, Julie"'

1. A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity

Author

Frayling, Timothy M., Lindgren, Cecilia M., Chevre, Jean Claude, Menzel, Stephan, Wishart, Marie, Benmezroua, Yamina, Brown, Alison, Evans, Julie C., Rao, Pamidghantam Subba, Dina, Christian, Lecoeur, Cécile, Kanninen, Timo, Almgren, Peter, Bulman, Michael P., Wang, Youxiang, Mills, James, Wright-Pascoe, Rosemarie, Mahtani, Melanie M., Prisco, Francesco, Costa, Angels, Cognet, Ignacio, Hansen, Torben, Pedersen, Oluf, Ellard, Sian, Tuomi, Tiinamaija, Groop, Leif C., Froguel, Philippe, Hattersley, Andrew T., and Vaxillaire, Martine

Published
2003

6. Β-Cell Genes and Diabetes

Author

Frayling, Timothy M., Evans, Julie C., Bulman, Michael P., Pearson, Ewan, Allen, Lisa, Owen, Katharine, Bingham, Coralie, Hannemann, Michael, Shepherd, Maggie, Ellard, Sian, and Hattersley, Andrew T.

Subjects
Diabetes -- Research, Pancreatic beta cells -- Genetic aspects -- Research, Genetic regulation -- Genetic aspects -- Research, Genetic transcription -- Genetic aspects -- Research, Type 2 diabetes -- Development and progression -- Research -- Genetic aspects, Health, Development and progression, Research, Genetic aspects
Abstract

Molecular and Clinical Characterization of Mutations in Transcription Factors Β-Cell transcription factor genes are important in the pathophysiology of the Β-cell, with mutations in hepatocyte nuclear factor (HNF)-1[Alpha], HNF-4[Alpha], insulin [...]

Published
2001

7. Variants within the NIDDM1 CAPN10 Diabetes-Susceptibility Gene Demonstrate Linkage and Association with Polycystic Ovarian Syndrome in European Trios

Author

HADDAD, LEMA, GHARANI, NEDA, EVANS, JULIE, CELA, ESTER, FRANKS, STEVE, and MCCARTHY, MARK

Subjects
Type 2 diabetes -- Development and progression, Disease susceptibility -- Genetic aspects, Health
Abstract

The NIDDM1 locus on chromosome 2q37 harbours a gene with major effects on type 2 diabetes susceptibility in Mexican-Americans (MA). Recently, the susceptibility variants have been mapped to the Calpain [...]

Published
2000

8. Variation in the Calpain 10 Gene Is Associated with Glucose Tolerance in Non-Diabetic European Caucasians

Author

WALKER, MARK, LYNN, STEPHEN, WHITE, CHRISTOPHER B., EVANS, JULIE C., and TURNBULL, DOUGLASS M.

Subjects
Glucose metabolism -- Genetic aspects, Type 2 diabetes -- Genetic aspects, Mexican Americans -- Health aspects, Health
Abstract

Recent studies suggest that genetic variation in the calpain 10 gene is associated with type 2 diabetes mellitus in Mexican American and other populations. We investigated whether G/A (UCSNP-43) and [...]

Published
2000

9. Transmission Disequilibruim at the Calpain10/NIDDDM1 Gene in UK Caucasian Type 2 Diabetes Parent-Offspring Trios

Author

FRAYLING, TIMOTHY M., EVANS, JULIE C., ELLARD, SIAN, and HATTERSLEY, ANDREW T.

Subjects
Type 2 diabetes -- Genetic aspects, Disease susceptibility -- Genetic aspects, Health
Abstract

Calpain 10 (CAPN10) has recently been identified as the NIDDM1 type 2 diabetes susceptibility gene in Mexican Americans. Initial studies identified SNP43 at position -4852 in intron 3 as a [...]

Published
2000

10. The Collection of Type 2 Diabetics with Both Parents Alive to Facilitate the Identification of Susceptibility Genes: the BDA Warren 2 Type 2 Diabetes Trios

Author

FRAYLING, TIMOTHY M, MCCARTHY, MARK, WALKER, MARK, EVANS, JULIE C, ALLEN, LISA I.S., AYRES, SUSAN, ELLARD, SIAN, and HATTERSLEY, ANDREW T

Subjects
Diabetes -- Research, Health
Abstract

Major susceptibility genes for Type 2 diabetes have not been described. Case/control association studies frequently result in false positive results due to population stratification. The Transmission Disequilibrium Test (TDT) is [...]

Published
1999

11. Functional Missense Mutations in the Insulin Promoter Factor 1 (IPF1) Gene Predispose to Type 2 Diabetes

Author

FRAYLING, TIMOTHY M, EVANS, JULIE C, ALLEN, LISA I.S., MACFARLANE, WENDY, DOCHERTY, KEVIN, MILWARD, ANNE, DEMAINE, ANDREW, WILKIN, TERRY J, AYRES, SUSAN, CLARK, PENNY, ELLARD, SIAN, and HATTERSLEY, ANDREW T

Subjects
Diabetes -- Research, Health
Abstract

The transcription factor insulin promoter factor 1 (IPF1) plays a key role in the development of the pancreas and the expression of beta-cell genes. In one pedigree a homozygous frameshift [...]

Published
1999

12. Parent-Offspring Trios.

Author

Frayling, Timothy M., Walker, Mark, McCarthy, Mark I., Evans, Julie C., Allen, Lisa I., Lynn, Steve, Ayres, Susan, Millauer, Barbara, Turner, Catherine, Turner[a],, Robert C., Sampson, Michael J., Hitman, Graham A., Ellard, Sian, and Hattersley, Andrew T.

Subjects
GENETICS of type 2 diabetes, HUMAN genetics
Abstract

Examines the prevalence, clinical characteristics, and suitability for defining type 2 susceptibility genes of European type 2 diabetes trios. Role of trios in defining genes in a number of polygenic conditions; Existence of polymorphisms that have been reported as showing association with type 2 diabetes; Clinical characteristics of type 2 trio probands.

Published
1999
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