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Introduction: Clinical studies have found disparities in gestational diabetes mellitus (GDM) outcomes due to individual racial and economic differences. In contrast, this pilot study examines the association of structures variations with GDM outcomes by race. Methods: Data were obtained from a healthcare system for a study population of 2,189 women with GDM, 18 years and above, singleton births, who delivered between January 1, 2014 and December 31, 2018. Clinical data were merged with structural measures of mothers’ census tracts of residence from the U.S. Census Bureau. Outcome variables are mother and infant birth complications. Data are analyzed using zero correlations by race. Results: Mother’s: white mothers tended to have fewer complications (r=-0.07, p Conclusion: Selected results show variations in complications among different races by neighborhood characteristics. The influence of race on GDM outcomes is linked to income and socioeconomic status. Income may be more important to GDM outcomes than race. Disclosure L. Thomas: None. M.R. Fawcett: None. C. Jurkovitz: None. J. Lenhard: Speaker’s Bureau; Self; Janssen Pharmaceuticals, Inc. Funding National Institutes of Health (U54GM104941)

Serum pigment epithelium-derived factor (PEDF) levels are correlated with adiposity, dyslipidemia, and renal dysfunction in type 2 diabetes (T2D) men. Major sources of circulating PEDF include the liver and adipose tissue. Cross-sectional studies have reported higher serum PEDF levels in T2D vs. controls. Although studies have suggested PEDF’s role in mediating insulin resistance, its potential role with regard to glycemic control remains unclear. We examined the association of serum PEDF and glycemic control in individuals with T2D (n=50; 21 men/29 women; age=63±10 years; CKD1.8; n=23; p1.8 (r=0.30, p=0.037), triglycerides (r=0.53, p1.8) was not (p=0.70). There was also a significant interaction of AST x creatinine (p=0.02). While some suggest that elevated PEDF levels are associated with insulin resistance, the lack of an association in our data is intriguing. It is possible that gluconeogenesis by the liver and kidney is associated with elevation in circulating PEDF and PEDF may be part of an incomplete self-defensive regulatory mechanism to limit hyperglycemia. The significant interaction suggests that the relationship between creatinine and PEDF depends on AST. Taken together, the association between PEDF and poor glycemic control in persons with T2D may suggest a preferentially protective compensatory response of PEDF against hyperglycemia but not insulin resistance. Disclosure R.E. Maser: None. J. Lenhard: Speaker's Bureau; Self; Eli Lilly and Company, Janssen Pharmaceuticals, Inc., Sanofi. R. Pohlig: None. P. Balagopal: None.