1. A Large Set of Finnish Affected Sibling Pair Families With Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14
- Author
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Richard M. Watanabe, Kerry R. Wiles, Kimberly Colby, Narisu Narisu, Julie A. Douglas, Leonid Segal, Tasha E. Fingerlin, Elizabeth R. Hauser, Pablo Hollstein, Kimberly F. Doheny, Victoria L. Magnuson, Kathleen M. Humphreys, Michael P. Epstein, Soumitra Ghosh, David Rha, Rachel Porter, Jason Tovar, Yong D. Suh, Jaakko Tuomilehto, William Hagopian, Francis S. Collins, Chun Li, Arun M. Unni, Carrie Pfahl, Laura J. Scott, Jason E. Hill, Anabelle Morales-Mena, George Lin, Thomas A. Buchanan, Konstantinos N. Lazaridis, Elizabeth W. Pugh, Peggy P. White, Roshni A. Kasad, Peter S. Chines, Anne U. Jackson, Kristin Patzkowski, Jessica Lambert, Michael R. Erdos, Heather M. Stringham, Timo T. Valle, Richard N. Bergman, Karen L. Mohlke, Kaisa Silander, Christian Welch, William L. Duren, and Michael Boehnke
- Subjects
Genetic Markers ,Male ,Positional cloning ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Internal Medicine ,Humans ,Family ,Genetic Predisposition to Disease ,Age of Onset ,Sibling ,Gene ,Finland ,Aged ,DNA Primers ,030304 developmental biology ,Chromosomes, Human, Pair 14 ,Linkage (software) ,Genetics ,0303 health sciences ,Affected sibling ,Base Sequence ,Genome, Human ,Chromosomes, Human, Pair 11 ,Siblings ,Chromosome ,Middle Aged ,Diabetes Mellitus, Type 2 ,Genetic marker ,Body Constitution ,Chromosomes, Human, Pair 6 ,Female ,Human genome - Abstract
The aim of the Finland-United States Investigation of NIDDM Genetics (FUSION) study is to identify genes that predispose to type 2 diabetes or are responsible for variability in diabetes-related traits via a positional cloning and positional candidate gene approach. In a previously published genome-wide scan of 478 Finnish affected sibling pair (ASP) families (FUSION 1), the strongest linkage results were on chromosomes 20 and 11. We now report a second genome-wide scan using an independent set of 242 Finnish ASP families (FUSION 2), a detailed analysis of the combined set of 737 FUSION 1 + 2 families (495 updated FUSION 1 families), and fine mapping of the regions of chromosomes 11 and 20. The strongest FUSION 2 linkage results were on chromosomes 6 (maximum logarithm of odds score [MLS] = 2.30 at 95 cM) and 14 (MLS = 1.80 at 57 cM). For the combined FUSION 1 + 2 families, three results were particularly notable: chromosome 11 (MLS = 2.98 at 82 cM), chromosome 14 (MLS = 2.74 at 58 cM), and chromosome 6 (MLS = 2.66 at 96 cM). We obtained smaller FUSION 1 + 2 MLSs on chromosomes X (MLS = 1.27 at 152 cM) and 20p (MLS = 1.21 at 20 cM). Among the 10 regions that showed nominally significant evidence for linkage in FUSION 1, four (on chromosomes 6, 11, 14, and X) also showed evidence for linkage in FUSION 2 and stronger evidence for linkage in the combined FUSION 1 + 2 sample.
- Published
- 2004
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