1. Control of Metabolism and Growth Through Insulin-Like Peptides inDrosophila
- Author
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May Ma, Mickael Ohanna, Maija Slaidina, Charles Géminard, Julien Colombani, Marc Bourouis, Marianne Bjordal, Pierre Léopold, Renald Delanoue, Nathalie Arquier, Sophie Layalle, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)
- Subjects
Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,medicine.medical_treatment ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Drosophila ,ComputingMilieux_MISCELLANEOUS ,Organism ,030304 developmental biology ,media_common ,0303 health sciences ,biology ,[SDV.BA]Life Sciences [q-bio]/Animal biology ,Insulin ,Longevity ,Metabolism ,biology.organism_classification ,medicine.disease ,Cell biology ,Insulin receptor ,Multicellular organism ,Biochemistry ,biology.protein ,030217 neurology & neurosurgery - Abstract
Insulin signaling is a conserved feature in all metazoans. It evolved with the appearance of multicellularity, allowing primordial metazoans to respond to a greater diversity of environmental signals. The insulin signaling pathway is highly conserved in insects and particularly in Drosophila, where it has been extensively studied in recent years and shown to control metabolism, growth, reproduction, and longevity. Because misregulation of the insulin/IGF pathway in humans plays a role in many medical disorders, such as diabetes and various types of cancer, unraveling the regulation of insulin/IGF signaling using the power of a genetically tractable organism like Drosophila may contribute to the amelioration of these major human pathologies.
- Published
- 2006
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