1. Low HDL Cholesterol Is Associated With the Risk of Stroke in Elderly Diabetic Individuals.
- Author
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Hayashi, Toshio, Kawashima, Seinosuke, Itoh, Hideki, Yamada, Nobuhiro, Sone, Hirohito, Watanabe, Hiroshi, Hattori, Yoshiyuki, Ohrui, Takashi, Yokote, Koutaro, Nomura, Hideki, Umegaki, Hiroyuki, and Iguchi, Akihisa
- Subjects
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DIABETES complications , *HIGH density lipoproteins , *CEREBROVASCULAR disease risk factors , *DIABETES in old age , *LIPIDS , *CORONARY disease , *GLUCOSE - Abstract
OBJECTIVE -- To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals. RESEARCH DESIGN AND METHODS -- The Japan Cholesterol and Diabetes Mellitus Study is a prospective cohort study of 4,014 type 2 diabetic patients (1,936 women; mean ± SD age 67.4 ± 9.5 years). Lipid and glucose levels and other factors were investigated in relation to occurrence of IHD or CVD. RESULTS -- IHD and CVD occurred in 1.59 and 1.43% of participants, respectively, over a 2-year period. The relation of lower HDL or higher LDL cholesterol to occurrence of IHD in subjects <65 years old was significant. Lower HDL cholesterol was also significantly related to CVD in subjects ≥65 years old and especially in those >75 years old (n = 1,016; odds ratio 0.511 [95% CI 0.239-0.918]; P < 0.05). Stepwise multiple regression analysis with onset of CVD as a dependent variable showed the same result. CONCLUSIONS -- Lower HDL cholesterol is an important risk factor for not only IHD but also CVD, especially in diabetic elderly individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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