1. Blunted Counterregulatory Hormone Responses to Hypoglycemia in Young Children and Adolescents With Well-Controlled Type 1 Diabetes
- Author
-
Roderick E. Warren, Alex Graveling, and Brian M. Frier
- Subjects
Advanced and Specialized Nursing ,Counterregulatory hormone ,medicine.medical_specialty ,Type 1 diabetes ,Pediatrics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Neuroglycopenia ,030209 endocrinology & metabolism ,Hypoglycemia ,medicine.disease ,Severe hypoglycemia ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,030225 pediatrics ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,Medicine ,business ,Pure autonomic failure ,Hormone - Abstract
In adults with insulin-treated diabetes, hypoglycemia-associated autonomic failure (HAAF) is described as a syndrome that includes counterregulatory hormonal deficiencies and impaired symptomatic awareness in response to severe hypoglycemia (1). It is thought to result from failure of the central autonomic response to acute neuroglycopenia and is associated with recurrent exposure to hypoglycemia and increasing duration of diabetes. It is not known whether this syndrome occurs in children with type 1 diabetes, but the Diabetes Research in Children Network (DirecNet) Study Group has claimed that HAAF was present in at least a third of their participants with type 1 diabetes (2). Examination of the study design and methodology raises …
- Published
- 2010
- Full Text
- View/download PDF