1. Comparison of fructosamine with glycosylated hemoglobin and plasma proteins as measures of glycemic control
- Author
-
Lesley M Smart, Robert J. Young, S W Walker, Basil F Clarke, Alistair F. Smith, and Alexander F. Howie
- Subjects
Adult ,endocrine system ,medicine.medical_specialty ,Glycosylation ,endocrine system diseases ,Adolescent ,Endocrinology, Diabetes and Metabolism ,chemistry.chemical_compound ,Internal medicine ,Diabetes mellitus ,Glycated Serum Proteins ,Internal Medicine ,medicine ,Humans ,Glycemic ,Aged ,Glycoproteins ,Advanced and Specialized Nursing ,Aged, 80 and over ,Glycated Hemoglobin ,business.industry ,Clinical Laboratory Techniques ,nutritional and metabolic diseases ,Hexosamines ,Blood Proteins ,Middle Aged ,medicine.disease ,Blood proteins ,Clinic visit ,Fructosamine ,Endocrinology ,Diabetes Mellitus, Type 1 ,chemistry ,Poor control ,Diabetes Mellitus, Type 2 ,Correlation analysis ,Hemoglobin ,business - Abstract
The relative value of fructosamine as an alternative to glycosylated hemoglobin (HbA1) and other measures of glycemic control was assessed in 100 insulin-dependent (IDDM) and 104 non-insulin-dependent (NIDDM) diabetic patients. We measured HbA1 (by electrophoretic and affinity methods), plasma glucose, glycosylated plasma proteins, and fructosamine in blood taken at a single clinic visit. The values were compared both by correlation analysis and by considering whether the various indices of glycemic control placed the patients in the same clinical decision categories as they were in by the HbA1 (affinity) result. Fructosamine correlated moderately well with HbA1 (affinity; r = .8) and placed 71% of IDDM and 72% of NIDDM patients in the same clinical category of good, moderate, or poor control. Differences can probably be partly attributed to the different periods over which HbA1 and fructosamine reflect average glycemia and partly to imprecision.
- Published
- 1988