1. The prevalence of NIDDM and associated risk factors in native Canadians
- Author
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Bernard Zinman, Anthony J. Hanley, Thomas M.S. Wolever, Annette Barnie, Alexander G. Logan, Joel Gittelsohn, Joe Gao, and Stewart B. Harris
- Subjects
Gerontology ,Adult ,Male ,medicine.medical_specialty ,endocrine system diseases ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Prevalence ,Body Mass Index ,Impaired glucose tolerance ,Age Distribution ,Risk Factors ,Diabetes mellitus ,Epidemiology ,Glucose Intolerance ,Internal Medicine ,medicine ,Humans ,Risk factor ,Sex Distribution ,Child ,Advanced and Specialized Nursing ,Ontario ,Analysis of Variance ,business.industry ,Public health ,nutritional and metabolic diseases ,Glucose Tolerance Test ,Middle Aged ,medicine.disease ,Obesity ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Body Composition ,Population study ,Body Constitution ,Female ,business ,Demography - Abstract
OBJECTIVE To determine the true prevalence of impaired glucose tolerance (IGT), NIDDM, and associated risk factors by age and sex in an isolated native community. RESEARCH DESIGN AND METHODS A community-wide prevalence survey using a 75-g oral glucose tolerance test (OGTT) was undertaken in the remote native reserve of Sandy Lake, Ontario, Canada. Measurements for obesity included waist-to-hip circumference, BMI, and percentage body fat. RESULTS A total of 728 individuals were enrolled, representing a community participation rate of 72%. The overall crude prevalence of NIDDM was 17.2% (18.1% females and 16.0% males) and increased to 26.1% overall (28.0% females and 24.2% males) when age-standardized. The prevalence of IGT was higher in females compared with males (age-standardized prevalence of 19.8 vs. 7.1%, respectively). Females had a higher prevalence of obesity, IGT, and NIDDM occurring at younger ages. Measures of obesity and fasting insulin levels were significantly associated with NIDDM in the 18–49 age-group. CONCLUSIONS The prevalence rates of NIDDM in this study population are the highest reported to date in a Canadian native population and among the highest reported in the world. Females appear to be at much higher risk of developing obesity, IGT, and NIDDM and at a younger age. Due to the high prevalence rates of IGT and NIDDM in this young population, there is urgent need to develop culturally appropriate community-based public health intervention programs before the long-term complications of diabetes have a devastating effect on the residents.
- Published
- 1997