1. Soluble endothelial protein C receptor and high sensitivity C reactive protein levels as markers of endothelial dysfunction in patients with type 1 and type 2 diabetes mellitus: their role in the prediction of vascular complications.
- Author
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Zaghloul A, Al-Bukhari TA, Al-Pakistani HA, Shalaby M, Halawani SH, Bajuaifer N, and Teama SH
- Subjects
- Adult, Biomarkers blood, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 physiopathology, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 physiopathology, Endothelial Protein C Receptor, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Vascular Diseases blood, Vascular Diseases physiopathology, Antigens, CD blood, C-Reactive Protein metabolism, Diabetes Mellitus, Type 1 complications, Diabetes Mellitus, Type 2 complications, Endothelium, Vascular physiopathology, Receptors, Cell Surface blood, Vascular Diseases etiology, Vasodilation physiology
- Abstract
Background and Objective: Endothelial dysfunction in diabetes mellitus (DM) is an important factor in the pathogenesis of micro and macrovascular complications. We aimed to measure soluble endothelial protein C receptor (sEPCR) and high sensitivity C reactive protein (hsCRP) levels as markers of endothelial damage in both types of diabetes mellitus and to determine if they can be used as predictors of vascular complications., Methods: Fifty patients with DM, 20 with type 1 and 30 with type 2 as well as 30 healthy subjects were included. All were subjected to measurement of sEPCR and hsCRP by enzyme linked immunosorbent assay., Results: sEPCR and hsCRP were significantly increased when compared to the control group in both types of DM. sEPCR was a significant predictor of macrovascular complications and thrombosis in type 1 p=0.02, and p=0.015, respectively. hsCRP was a significant predictor of macrovascular complications in type 2 p=0.04., Conclusion: Patients with type 1 and type 2 DM exhibit higher sEPCR and hsCRP levels compared to healthy controls which suggesting endothelial damage. sEPCR could be used as a predictor of macrovascular complications and thrombosis in type 1 DM, whereas, hsCRP might be used as a predictor of macrovascular complications in type 2 DM., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2014
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