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Start Over Author "Scidà, G" Journal diabetes research and clinical practice
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3. Postprandial glucose variability in type 1 diabetes: The individual matters beyond the meal

Author

L. Bozzetto, D. Pacella, L. Cavagnuolo, M. Capuano, A. Corrado, G. Scidà, G. Costabile, A.A. Rivellese, G. Annuzzi, Bozzetto, L, Pacella, D, Cavagnuolo, L, Capuano, M, Corrado, A, Scidà, G, Costabile, G, Rivellese, A A, and Annuzzi, G

Subjects
Blood Glucose, Dietary Fiber, Cross-Over Studies, Type 1 diabete, Endocrinology, Diabetes and Metabolism, Inter- intraindividual variability, General Medicine, Cross-Over Studie, Postprandial Period, Diet, Endocrinology, Diabetes Mellitus, Type 1, Glucose, Postprandial glucose response, Glycemic Index, Internal Medicine, Humans, Insulin, Insulin pump, Meal, Continuous glucose monitoring, Meals, Human
Abstract

To explore intraindividual (between-meals) and interindividual (between-subjects) variability of postprandial glucose response (PGR) in type 1 diabetes (T1DM).Data were taken from five cross-over trials in 61 subjects with T1DM on insulin pump wherein the effects of different dietary components or the intraindividual-variability of PGR to the same meal were evaluated by CGM. Predictors (type of meal or nutrient composition) of early (iAUCHigh-glycemic-index (HGI) and low-glycemic-index meals were the best positive and negative predictors of glucose iAUCBeyond the meal characteristics (including glycemic index, fat and fiber content), individual traits significantly influence PGR. Specific interindividual factors should be further identified to properly predict glucose response to meals with different composition in individuals with T1DM.

Published
2022

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