1. Physical activity level (PAL) and risk factors of cardiovascular disease in the MASHAD study cohort
- Author
-
Gordon A. Ferns, Azam Rastgar Moghadam, Fatemeh Sadabadi, Roshanak Ghaffarian Zirak, Sahar Ehyaei, Reza Zare-Feyzabadi, Hamideh Ghazizadeh, Fattaneh Tavassoli Fadihe, Mohsen Mouhebati, Majid Ghayour-Mobarhan, and Mohadese Rohban
- Subjects
Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Blood Pressure ,Iran ,Body Mass Index ,Cohort Studies ,Waist–hip ratio ,Risk Factors ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Exercise ,Heat-Shock Proteins ,Autoantibodies ,business.industry ,Waist-Hip Ratio ,Confounding ,General Medicine ,Anthropometry ,Middle Aged ,Physical activity level ,Cardiovascular Diseases ,Cohort ,Population study ,Female ,business ,Body mass index ,Biomarkers ,Cohort study ,Molecular Chaperones - Abstract
The relationship between physical activity levels (PAL) and the presence of cardiovascular disease (CVD) risk factors such as anthropometric and biochemical indices and heat shock proteins 27 antibody (anti-HSP-27) concentration, and serum inflammatory markers, was investigated in the MASHAD cohort study.The overall study population consisted of 9,684 subjects (3,858 men, 5,826 women) with a mean age of 47.73 ± 8.08 to 48.87 ± 9.26 years respectively. They were divided into four categories based on their PAL. Biochemical parameters were determined for all participants. Also, serum anti-HSP-27 levels were measured using an in-house enzyme-linked immune sorbent assay method. Multiple regression analysis was used to explore the association between the anti-HSP antibody titers and physical activity after adjusting for confounding factors. The level of statistical significance was set at p 0.05.Several CVD risk factors were associated with the level of PAL including: body mass index, waist hip ratio, systolic and diastolic blood pressure, serum HDL-C and TG (p 0.001) and also fasting blood glucose (0.004). Also, serum anti-HSP-27 titers were significantly higher in inactive subjects (P 0.05).We found that PAL was significantly associated with several established CVD risk factors. Also, the level of anti-HSP-27 was lower in individuals with moderate and high PAL.
- Published
- 2020