1. In-vitro validation of 4D flow MRI measurements with an experimental pulsatile flow model
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A. David, D. Le Touzé, Perrine Paul-Gilloteaux, Saïd Moussaoui, J.M. Serfaty, Karine Warin-Fresse, P. Guérin, Félicien Bonnefoy, Jérôme Idier, Service d'Imagerie cardiovasculaire [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Nord Laennec [CHU Nantes], Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Structure fédérative de recherche François Bonamy (SFR François Bonamy), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Santé de l'Université de Nantes (IRS-UN), Signal, IMage et Son (LS2N - équipe SIMS ), Laboratoire des Sciences du Numérique de Nantes (LS2N), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre hospitalier universitaire de Nantes (CHU Nantes), Paul-Gilloteaux, Perrine, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Signal, IMage et Son (SIMS ), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS)
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Pulsatile flow model ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Pulsatile flow ,Experimental studies ,Models, Biological ,Imaging phantom ,4D flow magnetic resonance imaging (MRI) ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Coronary Circulation ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Mean flow ,Image resolution ,Radiological and Ultrasound Technology ,Phantoms, Imaging ,business.industry ,Velocity encoding ,General Medicine ,Straight tube ,Magnetic Resonance Imaging ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,Flow (mathematics) ,Peak velocity ,Pulsatile Flow ,030220 oncology & carcinogenesis ,Phase-contrast magnetic resonance imaging ,business ,Blood Flow Velocity ,Biomedical engineering - Abstract
Purpose The purpose of this study was to assess the precision of four-dimensional (4D) phase-contrast magnetic resonance imaging (PCMRI) to measure mean flow and peak velocity (Vmax) in a pulsatile flow phantom and to test its sensitivity to spatial resolution and Venc. Material and methods The pulsatile flow phantom consisted of a straight tube connected to the systemic circulation of an experimental mock circulatory system. Four-dimensional-PCMR images were acquired using different spatial resolutions (minimum pixel size: 1.5 × 1.5 × 1.5 mm3) and velocity encoding sensitivities (up to three times Vmax). Mean flow and Vmax calculated from 4D-PCMRI were compared respectively to the reference phantom flow parameters and to Vmax obtained from two-dimensional (2D)-PCMRI. Results 4D-PCI measured mean flow with a precision of −0.04% to + 5.46%, but slightly underestimated Vmax when compared to 2D-PCMRI (differences ranging from −1.71% to −3.85%). 4D PCMRI mean flow measurement was influenced by spatial resolution (P Conclusion Using an experimental pulsatile flow model 4D-PCMRI is accurate to measure mean flow and Vmax with better results obtained with higher spatial resolution. We also show that Venc up to 3 times higher than Vmax may be used with no effect on these measurements.
- Published
- 2019
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