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The present study examined the in vitro activity of various antibiotics including zabofloxacin, against isolates responsible for invasive pneumococcal diseases. Between 1997 and 2008, a total of 208 isolates were collected from sterile fluids, including blood ( n = 196, 94.2%), pleural fluid ( n = 5, 2.4%), cerebrospinal fluid ( n = 5, 2.4%), and ascites ( n = 2, 1.0%). Zabofloxacin showed the lowest MIC 50 (0.015 μg/mL) and MIC 90 (0.025 μg/mL) values of all the tested antibiotics. Rates of isolates resistant to penicillin (MIC ≥8 μg/mL), ceftriaxone (MIC ≥4 μg/mL) and levofloxacin (MIC ≥8 μg/mL) were 3.4%, 0.4% and 2.0%, respectively. Four isolates (2.0%) were resistant to levofloxacin, and zabofloxacin showed low MICs (range, 0.025–0.125 μg/mL). Zabofloxacin shows potent in vitro activity against S. pneumoniae isolates that caused invasive disease, even strains that are resistant to levofloxacin. [ABSTRACT FROM AUTHOR]

Abstract: The in vitro activities of newer agents against 569 methicillin-resistant Staphylococcus aureus (MRSA) blood isolates stratified by vancomycin MIC values (≤1 versus >1 μg/mL) were evaluated using broth microdilution methods. All agents had good in vitro activities against MRSA regardless of vancomycin MIC values. Some significant correlations between vancomycin and newer agents'' MIC values were observed. [Copyright &y& Elsevier]

Abstract: We compared in vitro activities of carbapenems against 264 penicillin-resistant Streptococcus pneumoniae (PRSP) isolates. The MIC50/MIC90 (μg/mL) values of imipenem, meropenem, ertapenem, and panipenem were 1/1, 0.25/0.25, 0.25/0.5, and 0.125/0.25, respectively. The susceptibility rates to imipenem, meropenem, and ertapenem were 0%, 85.2%, and 99.6%, respectively. Compared with imipenem and meropenem, ertapenem and panipenem had better in vitro activities against PRSP. [Copyright &y& Elsevier]

The plasmid-mediated colistin resistance gene, mcr-1, was identified for the first time from a hospitalized patient in South Korea. The mcr-1 gene was successfully transferred to E. coli J53 recipient and conferred resistance to colistin in the recipient. The mcr-1 -harboring plasmid possessed a typical IncI2 group and did not have the mcr-1 -associated IS Apl1 element. [ABSTRACT FROM AUTHOR]