1. Pneumococcal diagnosis and serotypes in childhood community-acquired pneumonia.
- Author
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Elemraid MA, Sails AD, Thomas MF, Rushton SP, Perry JD, Eltringham GJ, Spencer DA, Eastham KM, Hampton F, Gennery AR, and Clark JE
- Subjects
- Adolescent, Child, Child, Preschool, Community-Acquired Infections prevention & control, Female, Humans, Male, Pneumococcal Vaccines administration & dosage, Pneumococcal Vaccines therapeutic use, Pneumonia, Pneumococcal immunology, Pneumonia, Pneumococcal prevention & control, Polymerase Chain Reaction, Prospective Studies, Serotyping, Streptococcus pneumoniae immunology, Vaccines, Conjugate administration & dosage, Vaccines, Conjugate immunology, Community-Acquired Infections diagnosis, Pneumonia, Pneumococcal diagnosis, Streptococcus pneumoniae isolation & purification
- Abstract
The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced routinely in the UK from September 2006 and replaced by PCV13 in 2010. In a prospective study from 2009 to 2011 of 160 children aged ≤16 years with radiologically confirmed pneumonia, likely pneumococcal infections were identified in 26%. Detection of pneumococci was improved with polymerase chain reaction compared to culture (21.6% versus 6% of children tested, P = 0.0004). Where serotyping was possible, all (n = 23) were non-PCV7 but PCV13 serotypes; 1 (43.5%), 3 (21.7%), 7A/F, and 19A (17.4% each)., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
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