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1. Contents Vol. 83, 2011

Author

Eiichiro Yamamoto, Christian Trautwein, Yumi Asano, I. Habibi, Imen Sfar, Kensuke Kubota, Walid Ben Aleya, Yael Mozer-Glassberg, Amar Mahgoub, Xiayue Huang, Hajime Isomoto, Corina Hartman, Mouna Makhlouf, Noritoshi Kobayashi, Antal Csepregi, Ali A. Siddiqui, Peter Malfertheiner, Lars Zimmermann, Leila Mouelhi, Hiroyuki Yamamoto, Jan Bornschein, Hiroshi Iida, Salwa Ayed-Jendoubi, Hirokazu Takahashi, Guoxin Zhang, Fuminao Takeshima, Kunihiro Hosono, Taoufik Najjar, Hiromi Kasugai, Atsushi Nakajima, Hermann E. Wasmuth, Zuhu Huang, R. Schirin-Sokhan, Yasunobu Abe, R. Rühl, Tomoko Koide, Jens J.W. Tischendorf, Yasuhisa Shinomura, Stefanie Tischendorf, Gerhard Rogler, Ron Winograd, Ken Ohnita, Hiroyuki Takamaru, Simon Wing Heng Li, Khaled Ayed, Taeib Ben Abdallah, Masahiko Inamori, Yasunari Sakamoto, Lijuan Xu, Tomayoshi Hayashi, Naoyuki Yamaguchi, Minoru Toyota, Koji Fujita, Mimi Chang, Jens Ricke, Raanan Shamir, Ruihua Shi, Takashi Uchiyama, Druck Reinhardt Druck Basel, Yoram Rosenbach, Noam Zevit, Kenta Iguchi, Jin Wang, Masato Yoneda, Hiromu Suzuki, Shin Maeda, Sara Morgenstern, Frank Tacke, Toshiyuki Nakayama, Shigeru Kohno, Saburo Shikuwa, Yousr Gorgi, Helene N. Pena Sahdala, H. Aouadi, Kazuhiko Nakao, Chikako Tokoro, Kerstin Schütte, Konrad L. Streetz, Ayumu Goto, and Hiroki Endo

Subjects
Gastroenterology
Published
2011
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2. Gastric Atrophy and Intestinal Metaplasia before and after Helicobacter pylori Eradication: A Meta-Analysis

Author

Rui-Hua Shi, Lijuan Xu, Guoxin Zhang, Xiayue Huang, Simon Wing Heng Li, Zuhu Huang, and Jin Wang

Subjects
medicine.medical_specialty, biology, business.industry, Gastric Atrophy, Gastroenterology, Review manager, Intestinal metaplasia, Helicobacter pylori, biology.organism_classification, medicine.disease, Weighted mean difference, Meta-analysis, Internal medicine, Medicine, Gastritis, medicine.symptom, business, Antrum
Abstract

Objective: Whether gastric atrophy (GA) and intestinal metaplasia (IM) are reversible after the eradication of Helicobacter pylori remains controversial. The purpose of this meta-analysis was to systematically review histological alterations in GA and IM by comparing histological scores before and after H. pylori eradication. Methods: English-language articles in the medical literature containing information about the association between infection with H. pylori and gastric premalignant lesions (i.e. GA and IM) were identified by searching the Medline, PubMed, and EMBASE databases with suitable key words up to December 2009. Review Manager 4.2.8 was used for the meta-analysis. Results: Twelve studies containing a total of 2,658 patients were included in the first meta-analysis. Before treatment, 2,648 patients had antrum GA, 2,401 patients had corpus GA, 2,582 patients had antrum IM, and 2,460 patients had corpus IM. Comparing the histological alterations before and after H. pylori eradication, the pooled weighted mean difference (WMD) with 95% CI for antral GA was 0.12 (0.00–0.23), p = 0.06. For corpus GA, the pooled WMD was 0.32 (0.09–0.54), p = 0.006. For antral IM, the pooled WMD was 0.02 (–0.12–0.16), p = 0.76, and for corpus IM, the pooled WMD was –0.02 (–0.05–0.02), p = 0.42. Conclusion: Our study shows that eradication of H. pylori results in significant improvement in GA in the corpus but not in the antrum; it also does not improve gastric mucous IM. Consequently, all patients with GA in the corpus should be tested for H. pylori infection, and eradication therapy should be prescribed for H. pylori-positive patients in those with GA in corpus.

Published
2011
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3. Gastric atrophy and intestinal metaplasia before and after Helicobacter pylori eradication: a meta-analysis

Author

Jin, Wang, Lijuan, Xu, Ruihua, Shi, Xiayue, Huang, Simon Wing Heng, Li, Zuhu, Huang, and Guoxin, Zhang

Subjects
Gastritis, Atrophic, Intestines, Metaplasia, Treatment Outcome, Helicobacter pylori, Stomach, Pyloric Antrum, Humans, Helicobacter Infections
Abstract

Whether gastric atrophy (GA) and intestinal metaplasia (IM) are reversible after the eradication of Helicobacter pylori remains controversial. The purpose of this meta-analysis was to systematically review histological alterations in GA and IM by comparing histological scores before and after H. pylori eradication.English-language articles in the medical literature containing information about the association between infection with H. pylori and gastric premalignant lesions (i.e. GA and IM) were identified by searching the Medline, PubMed, and EMBASE databases with suitable key words up to December 2009. Review Manager 4.2.8 was used for the meta-analysis.Twelve studies containing a total of 2,658 patients were included in the first meta-analysis. Before treatment, 2,648 patients had antrum GA, 2,401 patients had corpus GA, 2,582 patients had antrum IM, and 2,460 patients had corpus IM. Comparing the histological alterations before and after H. pylori eradication, the pooled weighted mean difference (WMD) with 95% CI for antral GA was 0.12 (0.00-0.23), p = 0.06. For corpus GA, the pooled WMD was 0.32 (0.09-0.54), p = 0.006. For antral IM, the pooled WMD was 0.02 (-0.12-0.16), p = 0.76, and for corpus IM, the pooled WMD was -0.02 (-0.05-0.02), p = 0.42.Our study shows that eradication of H. pylori results in significant improvement in GA in the corpus but not in the antrum; it also does not improve gastric mucous IM. Consequently, all patients with GA in the corpus should be tested for H. pylori infection, and eradication therapy should be prescribed for H. pylori-positive patients in those with GA in corpus.

Published
2009

4. Subject Index Vol. 83, 2011

Author

Khaled Ayed, Takashi Uchiyama, Taeib Ben Abdallah, Kenta Iguchi, Masahiko Inamori, Yumi Asano, Helene N. Pena Sahdala, Yasunobu Abe, Noritoshi Kobayashi, Xiayue Huang, Shin Maeda, Mimi Chang, Ali A. Siddiqui, Minoru Toyota, Kensuke Kubota, Walid Ben Aleya, Naoyuki Yamaguchi, Tomayoshi Hayashi, Yael Mozer-Glassberg, Sara Morgenstern, R. Rühl, Gerhard Rogler, Ayumu Goto, Hiroyuki Yamamoto, Chikako Tokoro, Masato Yoneda, Frank Tacke, Hiromu Suzuki, Shigeru Kohno, Saburo Shikuwa, Hirokazu Takahashi, Kerstin Schütte, Konrad L. Streetz, Yousr Gorgi, Hiroki Endo, Ken Ohnita, Fuminao Takeshima, Eiichiro Yamamoto, Kazuhiko Nakao, Toshiyuki Nakayama, Zuhu Huang, R Winograd, Kunihiro Hosono, Raanan Shamir, Imen Sfar, Simon Wing Heng Li, Ruihua Shi, Jens Ricke, Yasuhisa Shinomura, Druck Reinhardt Druck Basel, Noam Zevit, H. Aouadi, Hermann E. Wasmuth, Hajime Isomoto, Amar Mahgoub, Antal Csepregi, Corina Hartman, Mouna Makhlouf, Taoufik Najjar, Jan Bornschein, Peter Malfertheiner, Lars Zimmermann, R. Schirin-Sokhan, Salwa Ayed-Jendoubi, Hiroyuki Takamaru, Hiroshi Iida, Christian Trautwein, Jin Wang, Jens J. W. Tischendorf, Leila Mouelhi, Guoxin Zhang, Atsushi Nakajima, Tomoko Koide, Lijuan Xu, Yasunari Sakamoto, Koji Fujita, Yoram Rosenbach, I. Habibi, Stefanie Tischendorf, and Hiromi Kasugai

Subjects
Index (economics), Statistics, Gastroenterology, Subject (documents), Mathematics
Published
2011
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5. Gastric Atrophy and Intestinal Metaplasia before and after Helicobacter pylori Eradication: A Meta-Analysis.

Author

Jin Wang, Lijuan Xu, Ruihua Shi, Xiayue Huang, Simon Wing Heng Li, Zuhu Huang, and Guoxin Zhang

Subjects
SYSTEMATIC reviews, HELICOBACTER pylori, METAPLASIA, META-analysis, GASTROINTESTINAL diseases
Abstract

Objective: Whether gastric atrophy (GA) and intestinal metaplasia (IM) are reversible after the eradication of Helicobacter pylori remains controversial. The purpose of this meta-analysis was to systematically review histological alterations in GA and IM by comparing histological scores before and after H. pylori eradication. Methods: English-language articles in the medical literature containing information about the association between infection with H. pylori and gastric premalignant lesions (i.e. GA and IM) were identified by searching the Medline, PubMed, and EMBASE databases with suitable key words up to December 2009. Review Manager 4.2.8 was used for the meta-analysis. Results: Twelve studies containing a total of 2,658 patients were included in the first meta-analysis. Before treatment, 2,648 patients had antrum GA, 2,401 patients had corpus GA, 2,582 patients had antrum IM, and 2,460 patients had corpus IM. Comparing the histological alterations before and after H. pylori eradication, the pooled weighted mean difference (WMD) with 95% CI for antral GA was 0.12 (0.00-0.23), p = 0.06. For corpus GA, the pooled WMD was 0.32 (0.09-0.54), p = 0.006. For antral IM, the pooled WMD was 0.02 (-0.12-0.16), p = 0.76, and for corpus IM, the pooled WMD was -0.02 (-0.05-0.02), p = 0.42. Conclusion: Our study shows that eradication of H. pylori results in significant improvement in GA in the corpus but not in the antrum; it also does not improve gastric mucous IM. Consequently, all patients with GA in the corpus should be tested for H. pylori infection, and eradication therapy should be prescribed for H. pylori-positive patients in those with GA in corpus. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2011
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