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Your search keyword '"Manno M."' showing total 61 results
Start Over Author "Manno M." Journal digestive & liver disease
61 results on '"Manno M."'

5. Colo-rectal endoscopic full-thickness resection (EFTR) with the over-the-scope device (FTRD®): A multicenter Italian experience.

Author

Andrisani, G., Soriani, P., Manno, M., Pizzicannella, M., Pugliese, F., Mutignani, M., Naspetti, R., Petruzziello, L., Iacopini, F., Grossi, C., Lagoussis, P., Vavassori, S., Coppola, F., La Terra, A., Ghersi, S., Cecinato, P., De Nucci, G., Salerno, R., Pandolfi, M., and Costamagna, G.

Abstract

Abstract Background and aim Endoscopic full-thickness resection(EFTR) with FTRD® in colo-rectum may be useful for several indications.The aim was to assess its efficacy and safety. Material and methods In this retrospective multicenter study 114 patients were screened; 110 (61M/49F, mean age 68 ± 11 years, range 20–90) underwent EFTR using FTRD®. Indications were:residual/recurrent adenoma (39), incomplete resection at histology (R1 resection) (26), non-lifting lesion (12), adenoma involving the appendix (2) or diverticulum (2), subepithelial lesions(10), suspected T1 carcinoma (16), diagnostic resection (3). Technical success (TS: lesion reached and resected), R0 resection (negative lateral and deep margins),EFTR rate(all layers documented in the specimen) and safety have been evaluated. Results TS was achieved in 94.4% of cases. EFTR was achieved in 91% with lateral and deep R0 resection in 90% and 92%. Mean size of specimens was 20 mm (range 6–42). In residual/recurrent adenomas, final analysis revealed: low-risk T1 (11), adenoma with low-grade dysplasia (LGD) (24) and high-grade dysplasia (HGD) (3), scar tissue (1). Histology reports of R1 resections were: adenoma with LGD (6), with HGD (1), low-risk (6) and high-risk (1) T1, scar tissue (12). Non-lifting lesions were diagnosed as: adenoma with HGD (3), low-risk (7) and high risk (2) T1. Adverse clinical events occurred in 12 patients (11%),while adverse technical events in11%. Three-months follow-up was available in 100 cases and residual disease was evident in only seven patients. Conclusions EFTR using FTRD® seems to be a feasible, effective and safe technique for treating selected colo-rectal lesions. Comparative prospective studies are needed to confirm these promising results. [ABSTRACT FROM AUTHOR]

Published
2019
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9. Efficacy in intra-oesophageal acid suppression may decrease after 2-year continuous treatment with proton pump inhibitors.

Author

Frazzoni, M., Manno, M., De Micheli, E., and Savarino, V.

Subjects
BARRETT'S esophagus, ESOPHAGEAL abnormalities, GASTROESOPHAGEAL reflux, PROTON pump inhibitors
Abstract

Abstract: Background: Long-term intra-oesophageal acid suppression with proton pump inhibitors represents a management option for Barrett''s oesophagus and severe reflux oesophagitis, but its stability over time has not been adequately assessed. Aim: Our aim was to evaluate prospectively the efficacy of proton pump inhibitors in suppressing intra-oesophageal acidity after 2-year continuous treatment. Methods: Forty-five patients with Barrett''s oesophagus or severe reflux oesophagitis on a proton pump inhibitor regimen (once or twice daily) that normalised the total percentage acid exposure time were re-evaluated by means of 24-h oesophageal pH-monitoring after 2-year of continuous unmodified treatment. Results: A significant rise in the total percentage acid exposure time was observed at 2-year follow-up (P =0.029), owing to an increased value in 27 (60%) cases (9 on a twice daily regimen), higher than normal in 10 of them (22% of the whole group) (3 on a twice daily regimen). In 18 patients (40%) the total percentage acid exposure time was stable or decreased. Heartburn remained efficiently suppressed in all patients. Conclusions: The efficacy of proton pump inhibitors in suppressing intra-oesophageal acidity during continuous treatment may decrease over time, up to abnormal levels of oesophageal acid exposure in a minority of cases. This may occur without heartburn recurrence and with both once and twice daily regimens. [Copyright &y& Elsevier]

Published
2007
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10. Pathophysiological characteristics of the various forms of gastro-oesophageal reflux disease: Spectrum disease or distinct phenotypic presentations?

Author

Frazzoni, M., Manno, M., De Micheli, E., and Savarino, V.

Subjects
LIVER diseases, PHYSIOLOGY, DISEASES, PATIENTS
Abstract

Abstract: Background: The traditional approach to gastro-oesophageal reflux disease as a spectrum disease has recently been criticised and the distinct phenotypic presentations model has been proposed. Aim: To evaluate the main pathophysiological characteristics of various gastro-oesophageal reflux disease presentations. Methods: Oesophageal manometry and 24-h pH-monitoring were performed in a gastro-oesophageal reflux disease series collected in a 7-year period. Results: Four hundred and twenty-one subjects were studied. Mean total percentage acid reflux time was significantly higher in long-segment Barrett''s oesophagus and in ulcerative oesophagitis than in all the other gastro-oesophageal reflux disease groups, whilst in short-segment Barrett''s oesophagus results were quite similar to those found in non-erosive reflux disease and in erosive reflux disease. Patients with ulcerative oesophagitis and long-segment Barrett''s oesophagus were older than all the other gastro-oesophageal reflux disease groups. The mean lower oesophageal sphincter pressure was significantly reduced in non-erosive reflux disease, erosive reflux disease, ulcerative oesophagitis, short-segment Barrett''s oesophagus and long-segment Barrett''s oesophagus as compared with functional heartburn and hypersensitive oesophagus and with controls. Conclusions: In keeping with the spectrum model of gastro-oesophageal reflux disease, severity of acid reflux increases from non-erosive reflux disease through erosive reflux disease up to ulcerative oesophagitis and long-segment Barrett''s oesophagus. Ulcerative oesophagitis and long-segment Barrett''s oesophagus could represent an advanced step in the natural history of gastro-oesophageal reflux disease. Our results do not confirm the distinct phenotypic presentations hypothesis. [Copyright &y& Elsevier]

Published
2006
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11. Intra-oesophageal acid suppression in complicated gastro-oesophageal reflux disease: esomeprazole versus lansoprazole.

Author

Frazzoni, M., Manno, M., De Micheli, E., and Savarino, V.

Subjects
ESOPHAGEAL cancer, ESOPHAGUS, GASTROESOPHAGEAL reflux, PATIENTS
Abstract

Abstract: Background: Acid suppression is the mainstay of therapy in gastro-oesophageal reflux disease. Esomeprazole 40mg is more effective than lansoprazole 30mg in healing mucosal lesions in severe erosive reflux oesophagitis. However, data comparing esomeprazole with lansoprazole in patients with complications of gastro-oesophageal reflux disease, such as ulcerative reflux oesophagitis and Barrett''s oesophagus, are lacking. Aim: To compare the efficacy of esomeprazole and lansoprazole at their standard dosages in suppressing oesophageal acid exposure in complicated gastro-oesophageal reflux disease. Methods: Thirty patients with complicated gastro-oesophageal reflux disease (7 with ulcerative reflux oesophagitis and 23 with Barrett''s oesophagus), randomly assigned to receive 40mg esomeprazole (n =16) or 30mg lansoprazole (n =14) once daily, underwent oesophageal 24-h pH monitoring while on therapy. Total, upright diurnal and supine nocturnal percentage acid reflux time were assessed. Results: Esomeprazole was significantly more effective than lansoprazole in decreasing oesophageal acid exposure. Normalisation of both total and supine nocturnal percentage acid reflux time was obtained in 12 of 16 (75%) patients treated with esomeprazole but only in 4 of 14 (28%) cases treated with lansoprazole (p =0.026). Conclusions: Normalisation of oesophageal acid exposure can be achieved in the majority of complicated gastro-oesophageal reflux disease cases with esomeprazole 40mg once daily. [Copyright &y& Elsevier]

Published
2006
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24. P.10.1: Transfusion Strategy and Death Risk in Patients with Acute Non-Variceal Upper Gastro Intestinal Bleeding (NV-UGIB) in Italy: A Prospective Multicenter Observational Study.

Author

Marmo, R., Soncini, M., Bennato, R., Cipolletta, F., Orsini, L., Amitrano, L., Parente, F., Bargiggia, S., Paterlini, A., Cesaro, P., Bizzotto, A., Germanà, B., Cavallaro, L.G., Dell’Era, A., Costamagna, G., Riccioni, M.E., Marmo, C., Tortora, A., Manno, M., and Mangiafico, S.

Published
2017
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26. P.10.9: Outpatient Management of Patients with Glasgow-Blatchford Bleeding Score Low-Risk Upper-Gastrointestinal Hemorrhage: A Multicenter Validation Study in Italy.

Author

Marmo, R., Soncini, M., Orsini, L., Cipolletta, F., Bennato, R., Guardascione, M., Parente, F., Bargiggia, S., Paterlini, A., Cesaro, P., Bizzotto, A., Germanà, B., Cavallaro, L.G., Dell’Era, A., Costamagna, G., Riccioni, M.E., Marmo, C., Tortora, A., Manno, M., and Mangiafico, S.

Published
2017
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27. P.10.8: Mortality from Acute Upper Gastrointestinal Bleeding (UGIB): The Role of the Organizational and Health Care Course: A Prospective Multicentre Observational Study in Italy.

Author

Marmo, R., Soncini, M., Cipolletta, F., Orsini, L., Bennato, R., Guardascione, M., Parente, F., Bargiggia, S., Cesaro, P., Bizzotto, A., Germanà, B., Cavallaro, L.G., Dell’Era, A., Costamagna, G., Riccioni, M.E., Marmo, C., Tortora, A., Manno, M., Mangiafico, S., and Conigliaro, R.

Published
2017
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