1. Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment-A multicenter retrospective study
- Author
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Theresa Bucsics, Ioan Sporea, Carmine Tinelli, Thomas Reiberger, Giovanna Ferraioli, Annalisa De Silvestri, Robert J. de Knegt, Simon D. Taylor-Robinson, Sebastiana Atzori, Laura Maiocchi, Ruxandra Mare, Gastroenterology & Hepatology, and Imperial College Healthcare Charity
- Subjects
Liver Cirrhosis ,Male ,ACCURACY ,Chronic liver disease ,GUIDELINES ,Severity of Illness Index ,RECOMMENDATIONS ,0302 clinical medicine ,FIBROSIS ,Multicenter studies ,Gastroenterology ,Middle Aged ,Europe ,POINT QUANTIFICATION ,Concordance correlation coefficient ,Liver ,030220 oncology & carcinogenesis ,Area Under Curve ,Elasticity Imaging Techniques ,030211 gastroenterology & hepatology ,Female ,Guideline Adherence ,Diagnostic performance ,Viral hepatitis ,Life Sciences & Biomedicine ,CHRONIC HEPATITIS-C ,Adult ,Concordance ,Liver fibrosis ,SHEAR-WAVE ELASTOGRAPHY ,ULTRASOUND ELASTOGRAPHY ,DIAGNOSIS ,03 medical and health sciences ,CLINICAL-USE ,Severity of illness ,medicine ,Humans ,Aged ,Retrospective Studies ,Science & Technology ,Hepatology ,Receiver operating characteristic ,Gastroenterology & Hepatology ,business.industry ,Reproducibility of Results ,Retrospective cohort study ,1103 Clinical Sciences ,medicine.disease ,ROC Curve ,Shear wave elastography ,Quality criteria ,Transient elastography ,business ,Nuclear medicine - Abstract
BACKGROUND: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. AIMS: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ®) and (ii) impacts on the performance of ElastPQ® for liver fibrosis staging using TE as the reference standard. METHODS: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected. TE was performed with FibroScan® (Echosens, France) and ElastPQ® with EPIQ® or Affiniti® systems (Philips, The Netherlands). The agreement between TE and ElastPQ® LSMs was assessed with Lin's concordance correlation coefficient (CCC). Diagnostic performance of ElastPQ® was assessed by the area under receiver operating characteristic (AUROC) curves. RESULTS: Overall, 664 patients were included: mean age: 54.8(13.5) years, main etiologies: viral hepatitis (83.1%) and NAFLD (7.5%). CCC increased significantly when LSMs with ElastPQ® were obtained with IQR/M ≤ 30% (p
- Published
- 2018