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Start Over Author "Argüello, L" Journal digestive diseases and sciences
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2. On-demand therapy with rabeprazole in nonerosive and erosive gastroesophageal reflux disease in clinical practice: effectiveness, health-related quality of life, and patient satisfaction.

Author

Ponce J, Argüello L, Bastida G, Ponce M, Ortiz V, and Garrigues V

Subjects
2-Pyridinylmethylsulfinylbenzimidazoles, Adult, Esophagitis etiology, Esophagitis prevention & control, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Omeprazole analogs & derivatives, Patient Satisfaction, Prospective Studies, Quality of Life, Rabeprazole, Secondary Prevention, Severity of Illness Index, Treatment Outcome, Anti-Ulcer Agents administration & dosage, Benzimidazoles administration & dosage, Gastroesophageal Reflux drug therapy
Abstract

On-demand therapy is effective for maintaining symptoms control in nonerosive gastroesophageal reflux disease (GERD). Our aim was to assess the clinical effectiveness of on-demand therapy with a proton pump inhibitor (PPI) in mild GERD (nonerosive and low-grade esophagitis), its impact on health-related quality of life (HRQoL), and the degree of patient satisfaction. Fifty-five patients (17 with nonerosive GERD and 38 with low-grade esophagitis) were treated with rabeprazole, 20 mg/day. The healed patients started on-demand therapy. We evaluated symptoms (clinical questionnaire), HRQoL (SF-36 questionnaire), and patient satisfaction (visual analogue scale). Of the 55 patients included, 51 started on-demand therapy for 6 months. Symptom control (heartburn

Published
2004
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