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A thiocarboxamide derivative, pyridyl-2-thioacetamide, referred to as CMN 131, was characterized for its gastric antisecretory properties in rats and dogs. Its activity was first determined in 4-hr pylorus-ligated rats and in gastric fistula rats under basal and carbachol-stimulated (18 µg/kg/hr s.c.) conditions. ED50 of acid output inhibition was 1.46 (0.92–2.31) mg/kg by intraduodenal route and 3.85 (2.65–5.59) mg/kg s.c. respectively. The activity was further confirmed in Heidenhain-pouch dogs whose gastric secretion was stimulated by pentagastrin (3.20 µg/kg/hr i.v.) and histamine (160 µg/kg/hr i.v.). Under all these conditions, CMN 131 in doses ranging from 1 to 10 mg/kg, whatever the drug administration route, possesses a long-acting antisecretory property characterized first by an activity on acid concentration and second by an equal inhibitory potency on histamine and pentagastrin stimulation.