1. Role of Pancreatic Stone Protein as an Early Biomarker for Risk Stratification of Acute Pancreatitis
- Author
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Yok-Ai Que, Luis García de Guadiana-Romualdo, María Dolores Albaladejo-Otón, Senador Morán Sánchez, Virginia Algara Soriano, Josef Prazak, Carlos Rodríguez Rojas, and Romy Benninga
- Subjects
Adult ,medicine.medical_specialty ,Multivariate analysis ,Physiology ,macromolecular substances ,Disease ,Risk Assessment ,Severity of Illness Index ,Gastroenterology ,Predictive Value of Tests ,Internal medicine ,Lithostathine ,medicine ,Humans ,Urea ,Prospective Studies ,business.industry ,musculoskeletal, neural, and ocular physiology ,Area under the curve ,Emergency department ,Hepatology ,Prognosis ,medicine.disease ,Pancreatitis ,ROC Curve ,nervous system ,Acute Disease ,Biomarker (medicine) ,Acute pancreatitis ,Observational study ,business ,Biomarkers - Abstract
Early risk stratification of acute pancreatitis is crucial to improve clinical outcomes. The objective of this study was to evaluate the ability of pancreatic stone protein (PSP) to predict acute pancreatitis severity and to compare it with the biomarkers and severity scores currently used for that purpose. Prospective single-center observational study enrolling 268 adult patients with acute pancreatitis. Biomarkers including PSP were measured upon admission to the Emergency Department and severity scores as SOFA, PANC-3, and BISAP were computed. Patients were classified into mild-moderate (non-severe) and severe acute pancreatitis according to the Determinant-Based Classification Criteria. Area under the curve (AUC) and regression analysis were used to analyze the discrimination abilities and the association of biomarkers and scores with severity. Two hundred and thirty-five patients (87.7%) were classified as non-severe and 33 (12.3%) as severe acute pancreatitis. Median [IQR] PSP was increased in patients with severe acute pancreatitis (890 μg/L [559–1142] vs. 279 μg/L [141–496]; p
- Published
- 2021
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