1. Functional Gastrointestinal Symptoms Are Associated with Higher Serum Total IgE Levels, but Less Atopic Sensitization
- Author
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Ellen Johanne Vara, Marie Waatevik, Aud Katrine Herland Berstad, Ernst Omenaas, Erik Florvaag, Ane Johannessen, Gülen Arslan Lied, Cecilie Svanes, Trude Duelien Skorge, and Deborah Jarvis
- Subjects
Hypersensitivity, Immediate ,Male ,Allergy ,Physiology ,Immunoglobulin E ,Severity of Illness Index ,Gastroenterology ,Irritable Bowel Syndrome ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Young adult ,Irritable bowel syndrome ,Inhalation Exposure ,education.field_of_study ,biology ,Age Factors ,Middle Aged ,Up-Regulation ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Adult ,medicine.medical_specialty ,Adolescent ,Population ,Risk Assessment ,Young Adult ,03 medical and health sciences ,Sex Factors ,Internal medicine ,Severity of illness ,medicine ,Humans ,education ,Aged ,business.industry ,Case-control study ,Allergens ,Hepatology ,medicine.disease ,Case-Control Studies ,Multivariate Analysis ,Immunology ,biology.protein ,business ,human activities ,Biomarkers - Abstract
The relation of gastrointestinal (GI) complaints to IgE-mediated allergy is not well understood. Increased numbers of “IgE-armed” mast cells have been observed in duodenal mucosa of patients with functional GI complaints. To explore whether total IgE and atopic sensitization were associated with functional GI complaints. Levels of serum total and specific IgE and GI complaints were measured in 161 patients and in a general population sample of 478 persons. Standard inhalant allergens were measured in the patient group, and selected inhalant allergens in the general population. GI complaints were assessed by two standardized questionnaires. The associations between GI complaints and total IgE were analyzed in multiple regression models. GI complaints were positively associated with higher total IgE levels (all: b = 0.028, p = 0.012; patient group: b = 0.038, p = 0.072; general population: b = 0.038, p = 0.005), but negatively associated with atopic sensitization (all: b = −11.256, p = 0.181; patient group: b = −85.667, p
- Published
- 2015
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